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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03189
Abstract: We report a highly efficient copper-catalyzed three-component reaction of alkylamines, acetylenedicarboxylates, and α-bromocarbonyls for the assembly of fully substituted 1,3-dihydro-2H-pyrrol-2-ones. A variety of alkylamines and ammonium salt are functionalized with acetylenedicarboxylates and α-bromocarbonyls. N-aryl enaminoesters…
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Keywords:
fully substituted;
substituted dihydro;
dihydro pyrrol;
catalyzed three ... See more keywords
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Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00007h
Abstract: In this communication, we disclosed a palladium-catalyzed carbonylative procedure for the synthesis of 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones from propargyl amines and aryl halides. By using TFBen as the CO source, the reaction provides a facile and straightforward access…
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Keywords:
propargyl amines;
aryl dihydro;
dihydro pyrrol;
palladium catalyzed ... See more keywords
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Published in 2018 at "Chemistry Central Journal"
DOI: 10.1186/s13065-018-0452-z
Abstract: BackgroundTetramic acid, thiophene and hydrazone derivatives were found to exhibit favorable antifungal activity. Aiming to discover novel template molecules with potent antifungal activity, a series of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives containing a hydrazone group were designed,…
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Keywords:
pyrrol one;
dihydro pyrrol;
thiophen dihydro;
antifungal activity ... See more keywords