1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-cysteine Conjugates - Metabolic Formation and Binding to Cellular DNA.
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DOI: 10.1021/acs.chemrestox.0c00143
Abstract: 1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP) is a potential proximate carcinogenic metabolite of pyrrolizidine alkaloids. In the present study, we determined that reaction of 1-CHO-DHP with cysteine generated four identified products. By mass and 1H NMR spectral analysis, these… read more here.
Keywords: dhp; cho dhp; formyl hydroxy; dihydro pyrrolizine ... See more keywords