Redox Dyshomeostasis with Dual Stimuli‐Activatable Dihydroartemisinin Nanoparticles to Potentiate Ferroptotic Therapy of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200888
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to conventional therapies, including chemo‐, radio‐, and immunotherapy. In this study, it is first determined that a combination of dihydroartemisinin (DHA) and RSL‐3 (a glutathione peroxidase… read more here.
Keywords: tumor cells; therapy; redox dyshomeostasis; dha ... See more keywords
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113754
Abstract: A series of dihydroartemisinin derivatives was synthesized, and their anti-proliferation activity against cancer cells was evaluated. Structure-activity relationship studies led to the discovery of dihydroartemisinin-bile acid conjugates that exhibit broad-spectrum anti-proliferation activities. Among them, the… read more here.
Keywords: dihydroartemisinin; activity relationship; structure activity; acid ... See more keywords
A simple sensitive UFLC-MS/MS method for the simultaneous quantification of artesunate, dihydroartemisinin and quercetin in rat plasma and its application to pharmacokinetic studies
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07707c
Abstract: An ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous estimation of artesunate (ART), dihydroartemisinin (DHA, an active metabolite of ART) and quercetin (QRT) in rat plasma. read more here.
Keywords: dihydroartemisinin; rat plasma; quercetin; uflc method ... See more keywords
Self-assembled thioether-bridged paclitaxel-dihydroartemisinin prodrug for amplified antitumor efficacy-based cancer ferroptotic-chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02032g
Abstract: Ferroptosis has been proposed as one form of iron-dependent cell death, overgeneration of high-toxicity hydroxyl radicals (˙OH) tumor sites via Fenton reactions induced cell membrane damage. However, the insufficient intracellular concentrations of both iron and… read more here.
Keywords: ferroptotic chemotherapy; prodrug; paclitaxel; cancer ... See more keywords
Dihydroartemisinin induces ER stress-dependent apoptosis of Echinococcus protoscoleces in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa101
Abstract: In this study, we investigated the effect of dihydroartemisinin on Echinococcus protoscoleces and explored the role of endoplasmic reticulum stress in this process. Echinococcus protoscoleces were collected and cultured in RPMI 1640 medium. Changes in… read more here.
Keywords: echinococcus protoscoleces; caspase; apoptosis; microscopy ... See more keywords
Post-licensure safety evaluation of dihydroartemisinin piperaquine in the three major ecological zones across Ghana
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174503
Abstract: Background Uncommon and rare adverse events (AEs), with delayed onset may not be detected before new drugs are licensed and deployed. The present study examined the post licensure safety of dihydroartemisinin-piperaquine (DHP) as an additional… read more here.
Keywords: treatment; safety; study; dihydroartemisinin ... See more keywords
Dihydroartemisinin Induces ER Stress-Mediated Apoptosis in Human Tongue Squamous Carcinoma by Regulating ROS Production.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220215121341
Abstract: BACKGROUND Tongue squamous cell carcinoma is a fatal disease characterized by high invasion and early metastasis. Dihydroartemisinin, an antimalarial drug with multiple biological activities, is reported to be a potential anti-cancer agent. OBJECTIVE This study… read more here.
Keywords: tongue squamous; apoptosis; carcinoma; cell ... See more keywords
A Novel Antimalarial Metabolite in Erythrocyte From the Hydroxylation of Dihydroartemisinin by Cunninghamella elegans
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.850133
Abstract: Dihydroartemisinin (DHA) is a sesquiterpene endoperoxide with prominent antimalarial efficacy, which was discovered by Professor Youyou Tu through the reduction of artemisinin in the 1970s. It is always a challenging work for scientists to investigate… read more here.
Keywords: metabolites dha; cunninghamella; cunninghamella elegans; red blood ... See more keywords
Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.00047
Abstract: Dihydroartemisinin (DHA) is an active metabolite of sesquiterpene trioxane lactone extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate autophagy, which is the main mechanism to remove the damaged cell… read more here.
Keywords: dha treatment; degradation; alzheimer disease; dihydroartemisinin ... See more keywords
Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14081632
Abstract: The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression of dysplastic lesions. We evaluated the efficacy of topical dihydroartemisinin… read more here.
Keywords: papillomavirus; papillomavirus induced; mice; mouse models ... See more keywords