Widening the options for recurrent malaria
Sign Up to like & getrecommendations! Published in 2018 at "The Lancet"
DOI: 10.1016/s0140-6736(18)30630-5
Abstract: The global need for new antimalarial drugs and new combinations is enormous and urgent, but their successful delivery needs resilience to overcome the barriers imposed by expensive and lengthy clinical development plans. Attention is often… read more here.
Keywords: artesunate dihydroartemisinin; recurrent malaria; pyronaridine artesunate; artesunate ... See more keywords
Effect of dihydroartemisinin/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac081
Abstract: Abstract Background In sub-Saharan Africa, the burdens of malaria and HIV infections overlap. In settings with moderate-to-high malaria transmission intensity, pregnant women living with HIV (PLWH) require both ART and malaria intermittent preventive treatment (IPTp).… read more here.
Keywords: dolutegravir; pregnant women; dihydroartemisinin piperaquine; treatment ... See more keywords
Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria among Children in Western Kenya, 2016 to 2017
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00207-22
Abstract: Antimalarial resistance threatens global malaria control efforts. The World Health Organization (WHO) recommends routine antimalarial efficacy monitoring through a standardized therapeutic efficacy study (TES) protocol. ABSTRACT Antimalarial resistance threatens global malaria control efforts. The World… read more here.
Keywords: day; lumefantrine dihydroartemisinin; efficacy; artemether lumefantrine ... See more keywords
Impact of Dolutegravir-Based Antiretroviral Therapy on Piperaquine Exposure following Dihydroartemisinin-Piperaquine Intermittent Preventive Treatment of Malaria in Pregnant Women Living with HIV
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00584-22
Abstract: Dihydroartemisinin-piperaquine, an artemisinin-based combination therapy, has been identified as a promising agent for intermittent preventive treatment of malaria in pregnancy. However, in pregnant women living with HIV (PLWH), efavirenz-based antiretroviral therapy (ART) significantly reduces the… read more here.
Keywords: based art; therapy; pregnant women; dihydroartemisinin piperaquine ... See more keywords
Detection of Falsified Antimalarial Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine Drugs Using a Low-Cost Handheld Near-Infrared Spectrometer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/5335936
Abstract: Falsified drugs are of serious concern to public health worldwide, particularly for developing countries where quality control of drugs is inefficient. In law enforcement against such fake medicines, there is a need to develop reliable,… read more here.
Keywords: dihydroartemisinin piperaquine; near infrared; sulfadoxine pyrimethamine; low cost ... See more keywords
Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017–2018
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03585-6
Abstract: Background The World Health Organization recommends regularly assessing the efficacy of artemisinin-based combination therapy (ACT), which is a critical tool in the fight against malaria. This study evaluated the efficacy of two artemisinin-based combinations recommended… read more here.
Keywords: burkina faso; artemether lumefantrine; efficacy; lumefantrine dihydroartemisinin ... See more keywords
Post-licensure safety evaluation of dihydroartemisinin piperaquine in the three major ecological zones across Ghana
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174503
Abstract: Background Uncommon and rare adverse events (AEs), with delayed onset may not be detected before new drugs are licensed and deployed. The present study examined the post licensure safety of dihydroartemisinin-piperaquine (DHP) as an additional… read more here.
Keywords: treatment; safety; study; dihydroartemisinin ... See more keywords
A tablet derived from Andrographis paniculata complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of basic and clinical physiology and pharmacology"
DOI: 10.1515/jbcpp-2020-0162
Abstract: OBJECTIVES The use of standard antimalarial drugs, such as dihydroartemisinin-piperaquine (DHP) for the treatment of malaria during pregnancy is limited due to the risk of teratogenicity. The alternative is therefore required although few exist. Here we show… read more here.
Keywords: dhp; andrographis paniculata; treatment; treatment malaria ... See more keywords