1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.
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DOI: 10.1016/j.ejmech.2019.04.040
Abstract: The colchicine site inhibitors (CSIs) showed promising prospects as antitumor agents due to their vascular disrupting activities besides antimitotic activities. 1-Phenyl-dihydrobenzoindazole was found as a novel scaffold of CSI without the cis-trans isomerization problem. The… read more here.
Keywords: phenyl dihydrobenzoindazoles; site inhibitors; antitumor; colchicine site ... See more keywords