Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer’s Disease Transgenic Model
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2312-2
Abstract: ABSTRACTPurposeThe induction of autophagy has recently been explored as a promising therapeutic strategy to combat Alzheimer’s disease. Among many other factors, there is evidence that ceramides/dihydroceramides act as mediators of autophagy, although the exact mechanisms… read more here.
Keywords: desaturase inhibitors; desaturase; alzheimer disease; reduce amyloid ... See more keywords
Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.
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DOI: 10.1016/j.toxlet.2021.07.012
Abstract: Non-dialysable protein-bound uremic toxins (PBUTs) contribute to the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) and vice versa. PBUTs have been shown to alter sphingolipid imbalance. Dihydroceramide desaturase 1 (Des1) is an… read more here.
Keywords: uremic toxins; sphingolipid imbalance; inhibition; dihydroceramide desaturase ... See more keywords
The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106923
Abstract: Protein-bound uremic toxins (PBUTs) have adverse effects on vascular function, which is imperative in the progression of cardiovascular and renal diseases. The role of sphingolipids in PBUT-mediated vasculo-endothelial pathophysiology is unclear. This study assessed the… read more here.
Keywords: inhibition; effect dihydroceramide; indoxyl sulfate; dihydroceramide desaturase ... See more keywords