Characterization and assembly of the Pseudomonas aeruginosa aspartate transcarbamoylase-pseudo dihydroorotase complex
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DOI: 10.1371/journal.pone.0229494
Abstract: Pseudomonas aeruginosa is a virulent pathogen that has become more threatening with the emergence of multidrug resistance. The aspartate transcarbamoylase (ATCase) of this organism is a dodecamer comprised of six 37 kDa catalytic chains and… read more here.
Keywords: chain; pseudomonas aeruginosa; aspartate transcarbamoylase; atcase ... See more keywords
Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography.
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DOI: 10.2210/pdb6gdf/pdb
Abstract: Dihydroorotase (DHOase) is involved in the de novo synthesis of pyrimidine in virtually all organisms, and it is usually associated with two other enzymes found in this biosynthetic pathway, carbamylphosphate synthetase and/or aspartate transcarbamylase (ATCase).… read more here.
Keywords: high pressure; dihydroorotase; pressure induced; pressure ... See more keywords
Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS
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DOI: 10.3390/ijms22189984
Abstract: Drug-resistant Staphylococcus aureus is an imminent threat to public health, increasing the importance of drug discovery utilizing unexplored bacterial pathways and enzyme targets. De novo pyrimidine biosynthesis is a specialized, highly conserved pathway implicated in… read more here.
Keywords: staphylococcus aureus; small molecule; molecule inhibitors; dihydroorotase ... See more keywords