Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
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DOI: 10.1016/j.ejmech.2019.111881
Abstract: A scaffold hopping strategy converted the known 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidine core (1 and 2) by cyclization to a fused [6 + 5+6] membered heterocyclic mGluR2 PAM scaffold. Pharmacophore guided structure-activity relationship (SAR) studies resulted in a series of potent… read more here.
Keywords: discovery dihydropyrazino; metabotropic glutamate; dihydropyrazino benzimidazole; mglur2 ... See more keywords