Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment.
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DOI: 10.1016/j.bioorg.2021.105114
Abstract: We herein report a new synthetic route for a series of unreported 1,4-dihydropyrazolo[4,3-b]indoles (6-8) via deoxygenation of o-nitrophenyl-substituted N-aryl pyrazoles and subsequent intramolecular (sp2)-N bond formation under microwave irradiation expedite modified Cadogan condition. This method… read more here.
Keywords: bond formation; intramolecular sp2; indoles via; dft study ... See more keywords
New 1,4-Dihydropyrazolo[4,3-b]indoles Induce Antiproliferation of Acute Myeloid Leukemia Cells and Inhibition of Selective Inflammatory Cytokines
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DOI: 10.1177/1934578x221105692
Abstract: Research on multitargeting drugs is emerging, focusing on the discovery of agents that simultaneously act on more than one biological target. Here, a novel synthetic route to access the fused-heterocycles 1,4-dihydropyrazolo[4,3-b]indoles (4) from pyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide… read more here.
Keywords: dihydropyrazolo indoles; acute myeloid; myeloid leukemia; inhibition ... See more keywords