Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
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DOI: 10.1002/cmdc.202200034
Abstract: A series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on… read more here.
Keywords: plasmodium falciparum; glutathione reductase; dihydropyrimidinone; falciparum glutathione ... See more keywords
Synthesis of Novel 1,2,3-Triazole-Dihydropyrimidinone Hybrids Using Multicomponent 1,3-Dipolar Cycloaddition (Click)–Biginelli Reactions: Anticancer Activity
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DOI: 10.1055/s-0039-1690781
Abstract: In this work, 21 novel (1,4-disubstituted 1,2,3-triazole)-dihydropyrimidinone (1,2,3-trzl-DHPM) type hybrids were synthesized and characterized. These were divided into two types: hybrids A (5 in total) containing the dihydropyrimidinone heterocyclic ring decorated with a 1,4-disubstituted 1,2,3-triazole… read more here.
Keywords: dihydropyrimidinone; biginelli reactions; cycloaddition; cancer ... See more keywords
Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.624059
Abstract: Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms. Excessive or inappropriate TLR4 activation causes the development of many autoimmune diseases. Dihydropyrimidinone derivatives… read more here.
Keywords: dihydropyrimidinone; effect; compound; novel dihydropyrimidinone ... See more keywords