Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemistry"
DOI: 10.1155/2021/6664756
Abstract: In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and EI-MS. A… read more here.
Keywords: design synthesis; glucuronidase inhibitors; rational design; vitro silico ... See more keywords
Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s198865
Abstract: Purpose: To evaluate the antihepatotoxic activity of dihydropyrimidinone derivative linked with 1,4-benzodioxane. Methods: A series of novel dihydropyrimidinone derivatives linked with 1,4-benzodioxane moiety were synthesized in good yield. Modern spectroscopic techniques and elemental analysis were… read more here.
Keywords: antihepatotoxic activity; activity dihydropyrimidinone; activity; linked benzodioxane ... See more keywords
Investigation of anti-diabetic potential and molecular simulation studies of dihydropyrimidinone derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1022623
Abstract: In an attempt to find new targets for α-amylase and α-glucosidase for the treatment of type 2 diabetes mellitus, the present study aims in determining the anti-diabetic potential of synthesized dihydropyrimidinone derivatives. The in vitro… read more here.
Keywords: binding; anti diabetic; simulation studies; diabetic potential ... See more keywords