Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents
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DOI: 10.1002/ddr.21506
Abstract: In light of the pharmacophoric structural requirements for achieving anticonvulsant activity, a series of N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)benzamide (4a‐g) and N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)‐2‐phenylacetamide (4h‐n) derivatives were synthesized in two steps starting from the reaction of N‐methyl isatoic anhydride with the… read more here.
Keywords: vivo silico; synthesis vivo; evaluation novel; dihydroquinazolin one ... See more keywords
Cholinesulfuric acid ionic liquid catalyzed an eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-one in aqueous media
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-016-2849-4
Abstract: Abstract An efficient and straightforward approach to the synthesis of 2,3-dihydroquinazolin-4(1H)-one from 2-aminobenzamide and carbonyl compounds (aldehydes and ketones) using biocompatible choline sulfate-based acidic ionic liquid as a cheap and readily available catalyst in water… read more here.
Keywords: dihydroquinazolin one; ionic liquid; catalyst; synthesis dihydroquinazolin ... See more keywords
Practical approach to 2-thioxo-2,3-dihydroquinazolin-4(1H)-one via dithiocarbamate–anthranilic acid reaction
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DOI: 10.1016/j.cclet.2016.06.012
Abstract: A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic acid derivatives (2-aminobenzoic acid, 2-aminobenzamide and isatoic anhydride) with various dithiocarbamate… read more here.
Keywords: dithiocarbamate; thioxo dihydroquinazolin; dihydroquinazolin one; anthranilic acid ... See more keywords
Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin- 4(1H)-one derivatives as potential fXa inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.055
Abstract: Coagulation factor Xa (fXa) is a particularly attractive target for the development of effective and safe anticoagulants. In this study, novel 2,3-dihydroquinazolin-4(1H)-one derivatives were designed as potential fXa inhibitors based on anthranilamide structure which has… read more here.
Keywords: fxa inhibitors; fxa; one derivatives; dihydroquinazolin one ... See more keywords
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.04.045
Abstract: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few… read more here.
Keywords: design synthesis; trpm2 inhibitors; one derivatives; dihydroquinazolin one ... See more keywords
Solvent-Free, Mechanochemically Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Using Brønsted Acid Catalyst
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DOI: 10.1021/acssuschemeng.9b03199
Abstract: Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as challenging, the involvement of toxic solvents often triggers environmental safety concerns, resulting in process-engineering challenges. Herein, we have demonstrated a rapid, environmentally… read more here.
Keywords: synthesis; catalyst; dihydroquinazolin one; synthesis dihydroquinazolin ... See more keywords
Eucalyptol: An efficient, unexplored, green media for transition metal free synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives and isoxazolone derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Synthetic Communications"
DOI: 10.1080/00397911.2023.2197118
Abstract: Abstract Eucalyptol or 1,8-cineole, a bio-based monoterpene, whose potential has been explored as a viable alternative reaction media for the development of several heterocyclic systems. As an eco-benign solvent eucalyptol has been found to be… read more here.
Keywords: green media; isoxazolone derivatives; transition metal; dihydroquinazolin one ... See more keywords
Crystal structure of 3-benzyl-2-[(E)-2-(furan-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one and 3-benzyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one from synchrotron X-ray diffraction
Sign Up to like & getrecommendations! Published in 2018 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017017479
Abstract: The molecular and crystal structures of two 3-benzyl-2-[(E)-2-(2-aryl)ethenyl]-2,3-dihydroquinazolin-4-ones – products of three-component reactions between benzylamine, isatoic anhydride and furyl- or thienyl-acrolein in the presence of catalytic quantity of p-TsOH – were studied by X-ray diffraction. read more here.
Keywords: crystal structure; benzyl; ray diffraction; ethenyl dihydroquinazolin ... See more keywords