Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.046
Abstract: Sodium trifluoromethanesulfonate, and glacial acetic acid selectively catalyzed the synthesis of dihydroquinoline via Friedländer annulation. The synthesized dihydroquinoline analogues coupled with different amines by the use of coupling reagent gave dihydroquinoline carboxamide derivatives in moderate… read more here.
Keywords: carboxamide derivatives; anti tubercular; dihydroquinoline carboxamide; synthesis biological ... See more keywords
Transferrin-conjugated liposomes loaded with novel dihydroquinoline derivatives as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0186821
Abstract: A series of 1,2-dihydroquinoline derivatives were synthesized and evaluated for cytotoxicity in HeLa, Hep G2 and 6HEK-293T cell lines. EEDQ2 was identified as a promising anti-cancer agent with low IC50 in HeLa (18.55μg/ml) and Hep… read more here.
Keywords: dihydroquinoline derivatives; transferrin conjugated; liposomes loaded; conjugated liposomes ... See more keywords