Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights.
Sign Up to like & getrecommendations! Published in 2024 at "Future medicinal chemistry"
DOI: 10.1080/17568919.2024.2342707
Abstract: Aim: Synthesis of novel bis-Schiff bases having potent inhibitory activity against phosphodiesterase (PDE-1 and -3) enzymes, potentially offering therapeutic implications for various conditions. Methods: Bis-Schiff bases were synthesized by refluxing 2,4-dihydroxyacetophenone with hydrazine hydrate, followed… read more here.
Keywords: dihydroxyacetophenone; potent pde; dihydroxyacetophenone derivatives; synthesis ... See more keywords
Comparison between Electropolymers of 3,5-Dihydroxybenzoic Acid and 2′,6′-Dihydroxyacetophenone in Dimethyl Sulfoxide and Their Analytical Performance towards Selected Analytes with the Role of the Washing Liquid
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DOI: 10.3390/molecules29163972
Abstract: In the first part of this study, the electrochemical polymerization of two compounds, 3,5-dihydroxybenzoic acid and 2′,6′-dihydroxyacetophenone, was compared in dimethyl sulfoxide solvent on platinum and glassy carbon electrodes. The voltammograms obtained showed remarkable differences… read more here.
Keywords: dihydroxyacetophenone; washing liquid; solution; dihydroxybenzoic acid ... See more keywords