7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
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DOI: 10.1007/s11064-023-04090-9
Abstract: Vascular dementia (VD) is a degenerative cerebrovascular disorder associated with progressive cognitive decline. Previous reports have shown that 7,8-dihydroxyflavone (7,8-DHF), a well-known TrkB agonist, effectively ameliorates cognitive deficits in several disease models. Therefore, this study… read more here.
Keywords: vascular dementia; cholinergic dysfunction; oxidative stress; model ... See more keywords
Aging impairs dendrite morphogenesis of newborn neurons and is rescued by 7, 8‐dihydroxyflavone
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DOI: 10.1111/acel.12553
Abstract: All aging individuals will develop some degree of decline in cognitive capacity as time progresses. The molecular and cellular mechanisms leading to age‐related cognitive decline are still not fully understood. Through our previous research, we… read more here.
Keywords: dihydroxyflavone; newborn neurons; development newborn; aging impairs ... See more keywords
Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone
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DOI: 10.3389/fnut.2021.806623
Abstract: In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles… read more here.
Keywords: storage stability; zein glycosylated; dihydroxyflavone; glycosylated nanoparticles ... See more keywords
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
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DOI: 10.7554/elife.93094
Abstract: Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cognition… read more here.
Keywords: pdxp; vitamin; inhibitor; phosphatase ... See more keywords