The [4Fe‐4S]‐Cluster of HydF is not Required for the Binding and Transfer of the Diiron Site of [FeFe]‐Hydrogenases
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300222
Abstract: The active site of [FeFe]‐hydrogenases contains a cubane [4Fe‐4S]‐cluster and a unique diiron cluster with biologically unusual CO and CN− ligands. The biogenesis of this diiron site, termed [2FeH], requires the maturation proteins HydE, HydF… read more here.
Keywords: transfer; hydf; site; cluster ... See more keywords
Ethene-bridged diiron porphyrin dimer as models of diheme cytochrome c: Structure-function correlation and modulation of heme redox potential
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.09.047
Abstract: Abstract Multiheme cytochromes c are among the most fascinating molecular machineries evolved by Nature with essential functions in electron transfer and enzymatic catalysis. The multiheme architecture ensures fast intramolecular electron transfer over long distances. We… read more here.
Keywords: structure function; heme; diiron; diheme cytochrome ... See more keywords
On the importance of cyanide in diiron bridging carbyne complexes, unconventional [FeFe]-hydrogenase mimics without dithiolate: An electrochemical and DFT investigation
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119745
Abstract: Abstract A large number of catalysts for hydrogen evolution reaction (HER) that are related (structurally and/or functionally) to the active site of [FeFe]-hydrogenases (H-cluster) has been proposed in the past few decades. Very recently, a… read more here.
Keywords: dft; importance cyanide; carbyne; hydrogenase ... See more keywords
Computational Study of the C5-Hydroxylation Mechanism Catalyzed by the Diiron Monooxygenase PtmU3 as Part of the Platensimycin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c02407
Abstract: PtmU3 is a newly identified nonheme diiron monooxygenase, which installs a C-5 β-hydroxyl group into the C-19 CoA-ester intermediate involved in the biosynthesis of unique diterpene-derived scaffolds of platensimycin and platencin. PtmU3 possesses a noncanonical… read more here.
Keywords: diiron monooxygenase; biosynthesis; hydroxylation; fe1ii fe2iv ... See more keywords
Terminal Thiolate-Dominated H/D Exchanges and H2 Release: Diiron Thiol-Hydride.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06996
Abstract: To determine the reaction pathways at a metal-ligand site in enzymes, we incorporated a terminal thiolate site into a diiron bridging hydride. Trithiolato diiron hydride, (μ-H)Fe2(pdt)(dppbz)(CO)2(SR) (1(μ-H)) [pdt2- = 1,3-(CH2)3S22-, dppbz = 1,2-C6H4(PPh2)2, RS- =… read more here.
Keywords: diiron; terminal thiolate; site; thiol hydride ... See more keywords
New mechanistic insights into intramolecular aromatic ligand hydroxylation and benzyl alcohol oxidation initiated by the well-defined (μ-peroxo)diiron(iii) complex.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04382a
Abstract: A (μ-peroxo)diiron(iii) complex [Fe2(LPh4)(O2)(Ph3CCO2)]2+ (1-O2) with a dinucleating ligand (LPh4), generated from the reaction of a carboxylate bridged diiron(ii) complex [Fe2(LPh4)(Ph3CCO2)]2+ (1) with dioxygen in CH2Cl2, provides a diiron(iv)-oxo species as an active oxidant which… read more here.
Keywords: peroxo diiron; diiron iii; aromatic ligand; iii complex ... See more keywords
Functional models of nonheme diiron enzymes: reactivity of the μ-oxo-μ-1,2-peroxo-diiron(iii) intermediate in electrophilic and nucleophilic reactions.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/c9dt04551a
Abstract: The reactivity of the previously reported peroxo-adduct [FeIII2(μ-O)(μ-1,2-O2)(IndH)2(solv)2]2+ (1) (IndH = 1,3-bis(2-pyridyl-imino)isoindoline) has been investigated in nucleophilic (e.g., deformylation of alkyl and aryl alkyl aldehydes) and electrophilic (e.g. oxidation of phenols) stoichiometric reactions as biomimics… read more here.
Keywords: functional models; models nonheme; peroxo; nonheme diiron ... See more keywords
The Cytotoxic Activity of Diiron Bis-Cyclopentadienyl Complexes with Bridging C3-Ligands
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DOI: 10.3390/app11104351
Abstract: Diiron bis-cyclopentadienyl bis-carbonyl cationic complexes with a bridging vinyliminium ligand, [Fe2Cp2(CO)(μ-CO){μ-η1:η3-C3(R′)C2HC1NMe(R″)}]CF3SO3 (R = Xyl = 2,6-C6H3Me2, R′ = Ph, R″ = H, 2a; R = Xyl, R′ = R″ = Me, 2b; R = R′… read more here.
Keywords: diiron; bis cyclopentadienyl; activity; cell ... See more keywords
Disproportionation of H2O2 Mediated by Diiron-Peroxo Complexes as Catalase Mimics
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26154501
Abstract: Heme iron and nonheme dimanganese catalases protect biological systems against oxidative damage caused by hydrogen peroxide. Rubrerythrins are ferritine-like nonheme diiron proteins, which are structurally and mechanistically distinct from the heme-type catalase but similar to… read more here.
Keywords: h2o2; pyridyl imino; diiron peroxo; diiron ... See more keywords
Effect of Redox Potential on Diiron-Mediated Disproportionation of Hydrogen Peroxide
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DOI: 10.3390/molecules28072905
Abstract: Heme and nonheme dimanganese catalases are widely distributed in living organisms to participate in antioxidant defenses that protect biological systems from oxidative stress. The key step in these processes is the disproportionation of H2O2 to… read more here.
Keywords: disproportionation; redox potential; diiron iii; benzimidazole ... See more keywords