Tertiary phosphine‐supported diiron model complexes relevant to [FeFe]‐hydrogenases
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7608
Abstract: In an effort to better probe the structure–function relationship on the biological [Fe4S4] cluster of [FeFe]‐hydrogenases, a new library of tertiary phosphine‐supported diiron dithiolate complexes [Fe2(μ‐adtNR)(CO)5{P(C6H4X)3}] (1–3) with various substituents (X = F vs. H vs. Me),… read more here.
Keywords: phosphine supported; tertiary phosphine; fefe hydrogenases; diiron model ... See more keywords
The [4Fe‐4S]‐Cluster of HydF is not Required for the Binding and Transfer of the Diiron Site of [FeFe]‐Hydrogenases
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300222
Abstract: The active site of [FeFe]‐hydrogenases contains a cubane [4Fe‐4S]‐cluster and a unique diiron cluster with biologically unusual CO and CN− ligands. The biogenesis of this diiron site, termed [2FeH], requires the maturation proteins HydE, HydF… read more here.
Keywords: transfer; hydf; site; cluster ... See more keywords
Ethene-bridged diiron porphyrin dimer as models of diheme cytochrome c: Structure-function correlation and modulation of heme redox potential
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.09.047
Abstract: Abstract Multiheme cytochromes c are among the most fascinating molecular machineries evolved by Nature with essential functions in electron transfer and enzymatic catalysis. The multiheme architecture ensures fast intramolecular electron transfer over long distances. We… read more here.
Keywords: structure function; heme; diiron; diheme cytochrome ... See more keywords
On the importance of cyanide in diiron bridging carbyne complexes, unconventional [FeFe]-hydrogenase mimics without dithiolate: An electrochemical and DFT investigation
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119745
Abstract: Abstract A large number of catalysts for hydrogen evolution reaction (HER) that are related (structurally and/or functionally) to the active site of [FeFe]-hydrogenases (H-cluster) has been proposed in the past few decades. Very recently, a… read more here.
Keywords: dft; importance cyanide; carbyne; hydrogenase ... See more keywords
Computational Study of the C5-Hydroxylation Mechanism Catalyzed by the Diiron Monooxygenase PtmU3 as Part of the Platensimycin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c02407
Abstract: PtmU3 is a newly identified nonheme diiron monooxygenase, which installs a C-5 β-hydroxyl group into the C-19 CoA-ester intermediate involved in the biosynthesis of unique diterpene-derived scaffolds of platensimycin and platencin. PtmU3 possesses a noncanonical… read more here.
Keywords: diiron monooxygenase; biosynthesis; hydroxylation; fe1ii fe2iv ... See more keywords
Functional Nonheme Diiron(II) Complexes Catalyze the Direct Reduction of Nitrite to Nitric Oxide in Relevance to the Diiron Protein YtfE.
Sign Up to like & getrecommendations! Published in 2025 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.5c00753
Abstract: The present work reports the functional modeling chemistry of YtfE, which features a nonheme diiron active site and mediates the direct reduction of NO2- to NO. The model complex, [Fe2(HPTP)Cl2]1+ (1), reduces NO2- to NO… read more here.
Keywords: fe2 hptp; chemistry; hptp; reduction ... See more keywords
FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00377
Abstract: FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with an outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated cell lines, caused… read more here.
Keywords: carbyne complex; thio carbyne; anticancer; diiron thio ... See more keywords
Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c12910
Abstract: Azetidine is a strained four-membered N-heterocycle that has important applications in medicinal chemistry and organic synthesis. Despite its relevance to human health and agriculture, azetidine biosynthesis remains largely unexplored. Herein, the DUF6202 family enzyme PolF… read more here.
Keywords: ethylidene azetidine; iron; diiron; formation ... See more keywords
Terminal Thiolate-Dominated H/D Exchanges and H2 Release: Diiron Thiol-Hydride.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06996
Abstract: To determine the reaction pathways at a metal-ligand site in enzymes, we incorporated a terminal thiolate site into a diiron bridging hydride. Trithiolato diiron hydride, (μ-H)Fe2(pdt)(dppbz)(CO)2(SR) (1(μ-H)) [pdt2- = 1,3-(CH2)3S22-, dppbz = 1,2-C6H4(PPh2)2, RS- =… read more here.
Keywords: diiron; terminal thiolate; site; thiol hydride ... See more keywords
New mechanistic insights into intramolecular aromatic ligand hydroxylation and benzyl alcohol oxidation initiated by the well-defined (μ-peroxo)diiron(iii) complex.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04382a
Abstract: A (μ-peroxo)diiron(iii) complex [Fe2(LPh4)(O2)(Ph3CCO2)]2+ (1-O2) with a dinucleating ligand (LPh4), generated from the reaction of a carboxylate bridged diiron(ii) complex [Fe2(LPh4)(Ph3CCO2)]2+ (1) with dioxygen in CH2Cl2, provides a diiron(iv)-oxo species as an active oxidant which… read more here.
Keywords: peroxo diiron; diiron iii; aromatic ligand; iii complex ... See more keywords
Functional models of nonheme diiron enzymes: reactivity of the μ-oxo-μ-1,2-peroxo-diiron(iii) intermediate in electrophilic and nucleophilic reactions.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/c9dt04551a
Abstract: The reactivity of the previously reported peroxo-adduct [FeIII2(μ-O)(μ-1,2-O2)(IndH)2(solv)2]2+ (1) (IndH = 1,3-bis(2-pyridyl-imino)isoindoline) has been investigated in nucleophilic (e.g., deformylation of alkyl and aryl alkyl aldehydes) and electrophilic (e.g. oxidation of phenols) stoichiometric reactions as biomimics… read more here.
Keywords: functional models; models nonheme; peroxo; nonheme diiron ... See more keywords