Computational Study of the C5-Hydroxylation Mechanism Catalyzed by the Diiron Monooxygenase PtmU3 as Part of the Platensimycin Biosynthesis.
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DOI: 10.1021/acs.inorgchem.1c02407
Abstract: PtmU3 is a newly identified nonheme diiron monooxygenase, which installs a C-5 β-hydroxyl group into the C-19 CoA-ester intermediate involved in the biosynthesis of unique diterpene-derived scaffolds of platensimycin and platencin. PtmU3 possesses a noncanonical… read more here.
Keywords: diiron monooxygenase; biosynthesis; hydroxylation; fe1ii fe2iv ... See more keywords