Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
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DOI: 10.1021/acs.jmedchem.1c00535
Abstract: Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents a validated and promising target,… read more here.
Keywords: reverse transcriptase; rnase; non diketo; diketo ... See more keywords
Reinvestigation of the Biomimetic Cyclization of 3,5-Diketo Esters: Application to the Total Synthesis of Cyercene A, an α-Methoxy-γ-Pyrone-Containing Polypropionate
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DOI: 10.1055/s-0036-1588795
Abstract: The biomimetic cyclization of 3,5-diketo esters was reinvestigated for the synthesis of α-methoxy-γ-pyrones. 3,5-Diketo esters were selectively synthesized via the aldol reaction of commercially available methyl 2-methyl-3-oxopentanoate with an aldehyde followed by the oxidation with… read more here.
Keywords: biomimetic cyclization; cyclization diketo; diketo esters; diketo ... See more keywords
Residue depletion of amoxicillin and its major metabolites in eggs
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DOI: 10.1111/jvp.12363
Abstract: The depletion of amoxicillin (AMO) and its major metabolites, amoxicilloic acid (AMA) and amoxicillin-diketopiperazine-2',5'-dione (DIKETO) in the albumen, yolk and whole egg was studied after the oral dose of AMO (25 and 50 mg/kg body weight)… read more here.
Keywords: amoxicillin major; residue depletion; diketo; depletion amoxicillin ... See more keywords
Synthesis of 1,3-diketo derivatives of calix[4]arene with nonyl substituents at the lower rim as novel efficient sensibilizers of Tb3+ luminescence
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DOI: 10.1134/s1070363217090110
Abstract: Novel bis- and tetra-1,3-diketo derivatives of calix[4]arene with nonyl substituents at the lower rim have been synthesized. Their conformational and tautomeric composition have been determined; spectral parameters and complex formation properties with Tb3+ have been… read more here.
Keywords: derivatives calix; calix arene; diketo derivatives; arene nonyl ... See more keywords