Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03919
Abstract: An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds… read more here.
Keywords: arynes diketo; indanes arynes; diketo esters; functionalized indanes ... See more keywords
Reinvestigation of the Biomimetic Cyclization of 3,5-Diketo Esters: Application to the Total Synthesis of Cyercene A, an α-Methoxy-γ-Pyrone-Containing Polypropionate
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DOI: 10.1055/s-0036-1588795
Abstract: The biomimetic cyclization of 3,5-diketo esters was reinvestigated for the synthesis of α-methoxy-γ-pyrones. 3,5-Diketo esters were selectively synthesized via the aldol reaction of commercially available methyl 2-methyl-3-oxopentanoate with an aldehyde followed by the oxidation with… read more here.
Keywords: biomimetic cyclization; cyclization diketo; diketo esters; diketo ... See more keywords