Highly Modular Synthesis of 1,2-Diketones via Multicomponent Coupling Reactions of Isocyanides as CO Equivalents
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DOI: 10.1021/acscatal.9b00581
Abstract: A one-pot, four-component Pd-catalyzed coupling has been developed for the synthesis of unsymmetrical 1,2-diketones from aryl halides and alkyl zincs employing tert-butyl isocyanide as a CO source. The intermediate 1,2-diketones have been elaborated to quinoxalines.… read more here.
Keywords: synthesis; synthesis diketones; diketones via; via multicomponent ... See more keywords
Facile synthesis of 1,4-diketones via three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water
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DOI: 10.1039/c7gc03644b
Abstract: Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way. Many compounds, such as indole, azaindole, pyrrole, 2-methylfuran, N,N-dimethylaniline, N-methylaniline, thiophenol,… read more here.
Keywords: diketones via; via three; facile synthesis; synthesis diketones ... See more keywords
Synthesis of 1,4-Diketones via Titanium-Mediated Reductive Homocoupling of α-Haloketones
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DOI: 10.1055/s-0037-1610245
Abstract: 1,4-Diketones have been synthesized via a reductive homocoupling of α-haloketones. Addition of a Grignard reagent to titanium(IV) isopropoxide affords a low-valent titanium(III) intermediate that is believed to mediate a radical dimerization reaction. The reaction works… read more here.
Keywords: diketones via; via titanium; reductive homocoupling; synthesis diketones ... See more keywords