Genomics‐Guided Efficient Identification of 2,5‐Diketopiperazine Derivatives from Actinobacteria
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200502
Abstract: Secondary metabolites derived from microorganism constitute an important part of natural products. Mining of the microbial genomes revealed a large number of uncharacterized biosynthetic gene clusters, indicating their greater potential to synthetize specialized or secondary… read more here.
Keywords: identification diketopiperazine; efficient identification; identification; diketopiperazine derivatives ... See more keywords
Identification of new 2,5-diketopiperazine derivatives as simultaneous effective inhibitors of αβ-tubulin and BCRP proteins: Molecular docking, Structure−Activity Relationships and virtual consensus docking studies
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DOI: 10.1016/j.molstruc.2017.02.049
Abstract: Abstract In the first part of this paper, docking method was employed in order to study the binding mechanism of breast cancer resistance protein (BCRP) with a group of previously synthesized TPS-A derivatives which known… read more here.
Keywords: bcrp; binding site; diketopiperazine derivatives; tubulin bcrp ... See more keywords
Biological activity and interaction mechanism of the diketopiperazine derivatives as tubulin polymerization inhibitors
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DOI: 10.1039/c7ra12173c
Abstract: Microtubules are a favorable target for development of anticancer agents. In this study, the anti-proliferative activities of plinabulin and six diketopiperazine derivatives were evaluated against human lung cancer cell line NCI-H460 and human pancreatic cancer… read more here.
Keywords: polymerization; polymerization inhibitors; diketopiperazine derivatives; derivatives tubulin ... See more keywords