Nondestructive Optical Toxicity Assays of 3D Liver Spheroids with Optical Coherence Tomography
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700212
Abstract: Drug‐induced liver injury (DILI) is the leading cause of failure in preclinical drug development and withdrawals. Given the central role of the liver in drug metabolism and detoxification, strong incentives exist to create new physiologically… read more here.
Keywords: coherence tomography; optical coherence; dili; liver spheroids ... See more keywords
Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200986
Abstract: Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual probiotics system are fabricated by sequentially encapsulating probiotic Lactobacillus delbrueckii… read more here.
Keywords: drug induced; gut; dili; cholestatic drug ... See more keywords
Lymphocyte profile and immune checkpoint expression in drug-induced liver injury: an immunophenotyping study.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2423
Abstract: The identification of specific human leukocyte antigen (HLA) risk alleles in drug-induced liver injury (DILI) points towards an important role of the adaptive immune system in DILI development. In this study we aimed to corroborate… read more here.
Keywords: immune checkpoint; induced liver; drug induced; liver injury ... See more keywords
A revised electronic version of RUCAM for the diagnosis of DILI
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32327
Abstract: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug‐Induced Liver Injury Network (DILIN) and the Spanish DILI… read more here.
Keywords: electronic version; dili; rucam diagnosis; revised electronic ... See more keywords
In Silico Identification of Proteins Associated with Drug‐induced Liver Injury Based on the Prediction of Drug‐target Interactions
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DOI: 10.1002/minf.201600142
Abstract: Drug‐induced liver injury (DILI) is the leading cause of acute liver failure as well as one of the major reasons for drug withdrawal from clinical trials and the market. Elucidation of molecular interactions associated with… read more here.
Keywords: liver injury; drug induced; drug; drug target ... See more keywords
In silico prediction of drug-induced liver injury with a complementary integration strategy based on hybrid representation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular informatics"
DOI: 10.1002/minf.202200284
Abstract: Drug-induced liver injury (DILI) is one of the major causes of drug withdrawals, acute liver injury and blackbox warnings. Clinical diagnosis of DILI is a huge challenge due to the complex pathogenesis and lack of… read more here.
Keywords: dili; liver injury; integration; prediction ... See more keywords
The application of cytokeratin-18 as a biomarker for drug-induced liver injury
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Toxicology"
DOI: 10.1007/s00204-021-03121-0
Abstract: Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading cause of candidate drug attrition, withdrawal and in clinic, is the primary cause… read more here.
Keywords: biomarker; drug induced; drug; injury ... See more keywords
Role of liver biopsy in the era of clinical prediction scores for “drug-induced liver injury” (DILI): experience of a tertiary referral hospital
Sign Up to like & getrecommendations! Published in 2020 at "Virchows Archiv"
DOI: 10.1007/s00428-020-02824-6
Abstract: The clinical implications of the biopsy findings in cases of drug-induced liver injury (DILI) are not fully elucidated. The aim of this study was to evaluate the histopathological findings of cases diagnosed as DILI and… read more here.
Keywords: liver injury; drug induced; liver biopsy; induced liver ... See more keywords
MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03988-0
Abstract: MiR-122-5p serves as a novel biomarker for drug-induced liver injury (DILI), but its function in DILI remains unclear. The present study, therefore, explored the function and potential mechanism of miR-122-5p in DILI. Sprague-Dawley (SD) rats… read more here.
Keywords: liver injury; dili; mir 122; 122 knockdown ... See more keywords
Initial observations of water quality indicators in the unconfined shallow aquifer in Dili City, Timor-Leste: suggestions for its management
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Earth Sciences"
DOI: 10.1007/s12665-018-7902-8
Abstract: The management of groundwater quality is a critical issue in developing nations where sanitation and drinking water targets are commonly addressed by facilitating access to groundwater, which is then managed as a common-pool resource. We… read more here.
Keywords: quality; groundwater; water; management ... See more keywords
Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2021.10.035
Abstract: Drug-induced liver injury (DILI) is an important but rare adverse event which can range from mild liver enzyme elevations to liver failure, transplantation or death. A large proportion of commonly used medications, in addition to… read more here.
Keywords: induced liver; drug induced; epidemiology; liver injury ... See more keywords