Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.
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DOI: 10.1016/j.ejmech.2020.113017
Abstract: Multidrug resistance membrane pumps reduce the efficacy of chemotherapies by exporting a wide panel of structurally-divergent drugs. Here, to take advantage of the polyspecificity of the human Breast Cancer Resistance Protein (BCRP/ABCG2) and the dimeric… read more here.
Keywords: human breast; cancer resistance; breast cancer; resistance ... See more keywords