LAUSR

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

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0 Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101887

Abstract: Summary Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise cleavage lines by γ-secretase.… read more here.

Keywords: dimeric transmembrane; secretase; processing; processing line ... See more keywords