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   Articles with "dimerization" as a keyword



ERK1/2 mitogen‐activated protein kinase dimerization is essential for the regulation of cell motility

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13732

Abstract: ERK1/2 mitogen‐activated protein kinases (ERK) are key regulators of basic cellular processes, including proliferation, survival, and migration. Upon phosphorylation, ERK becomes activated and a portion of it dimerizes. The importance of ERK activation in specific… read more here.

Keywords: cell motility; kinase; dimerization; erk1 mitogen ... See more keywords

Dimerization facilitates the conformational transitions for bacterial phosphotransferase enzyme I autophosphorylation in an allosteric manner

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12260

Abstract: The bacterial phosphotransferase system is central to sugar uptake and phosphorylation. Enzyme I (EI), the first enzyme of the system, autophosphorylates as a dimer using phosphoenolpyruvate (PEP), but it is not clearly understood how dimerization… read more here.

Keywords: bacterial phosphotransferase; dimerization; allosteric manner; autophosphorylation ... See more keywords

Monodentate Phosphinoamine Nickel Complex Supported on a Metal–Organic Framework for High‐Performance Ethylene Dimerization

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202309540

Abstract: Ethylene dimerization is an efficient industrial chemical process to produce 1‐butene, with demanding selectivity and activity requirements on new catalytic systems. Herein, a series of monodentate phosphinoamine‐nickel complexes immobilized on UiO‐66 are described for ethylene… read more here.

Keywords: catalyst; monodentate phosphinoamine; ethylene dimerization; phosphinoamine nickel ... See more keywords

Dimerization of Proline Dehydrogenase from Thermus thermophilus Is Crucial for Its Thermostability.

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recommendations! Published in 2019 at "Biotechnology journal"

DOI: 10.1002/biot.201800540

Abstract: Thermus thermophilus proline dehydrogenase ( TtProDH) catalyzes the first step in proline catabolism. The thermostable flavoenzyme consists of a distorted triosephosphate isomerase (TIM) barrel and three N-terminal helices: αA, αB, and αC. Using maltose-binding protein… read more here.

Keywords: proline dehydrogenase; dimerization; thermostability; thermus ... See more keywords
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Engineering soluble artificial epidermal growth factor receptor mimics capable of spontaneous in vitro dimerization

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recommendations! Published in 2020 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.27659

Abstract: Epidermal growth factor receptor (EGFR) is a clinically validated target for a multitude of human cancers. The receptor is activated upon ligand binding through a critical dimerization step. Dimerization can be replicated in vitro by… read more here.

Keywords: dimerization; kinase; factor receptor; growth factor ... See more keywords

Synthesis of dibenzo[a,j]phenazine compounds using hemicucurbit[6]uril‐catalyzed oxidative dimerization of 2‐arylamines

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recommendations! Published in 2020 at "ChemCatChem"

DOI: 10.1002/cctc.202000956

Abstract: A supramolecular catalytic strategy for the synthesis of dibenzo[a,j]phenazine compounds from 2‐arylamines is demonstrated. The dimerization is achieved through the catalytic action of HemiQ[6] in an acidic environment. Kinetic constants and activation energies have been… read more here.

Keywords: synthesis dibenzo; dibenzo phenazine; dimerization; phenazine compounds ... See more keywords

Ethylene Dimerization, Isomerization and Trimerization: Mechanistic Insights into Competing Pathways on Metal–Organic Framework Supported Metal Hydrides

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recommendations! Published in 2024 at "ChemCatChem"

DOI: 10.1002/cctc.202400906

Abstract: Catalytic ethylene oligomerization is important in the petrochemical industry, as it produces valuable products like linear alpha‐olefins (LAOs) for the synthesis of polymers and specialty chemicals. Catalysts, typically transition metal complexes or metal‐containing materials, play… read more here.

Keywords: ethylene oligomerization; metal; trimerization; isomerization ... See more keywords
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Electronic processes in NO dimerization on Ag and Cu clusters: DFT and MRMP2 studies

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recommendations! Published in 2019 at "Journal of Computational Chemistry"

DOI: 10.1002/jcc.25568

Abstract: Experimentally observed NO dimerization on Cu and Ag surfaces is surprising because binding energy of NO dimer is very small in gas phase. MRMP2, MP2 to MP4, CCSD(T), and DFT studies of NO dimerization on… read more here.

Keywords: order; energy; dimerization; cu2 ... See more keywords

Characterization of the role of Kunitz‐type protease inhibitor domain in dimerization of amyloid precursor protein

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recommendations! Published in 2023 at "Journal of Computational Chemistry"

DOI: 10.1002/jcc.27100

Abstract: A major difference between amyloid precursor protein (APP) isoforms (APP695 and APP751) is the existence of a Kunitz type protease inhibitor (KPI) domain which has a significant impact on the homo‐ and hetero‐dimerization of APP… read more here.

Keywords: amyloid precursor; domain; dimerization; precursor protein ... See more keywords

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif

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recommendations! Published in 2019 at "Protein Science"

DOI: 10.1002/pro.3593

Abstract: We previously described structural and functional characterization of the first ubiquitin variant (UbV), UbV.v27.1, engineered by phage display to bind with high affinity to a specific ubiquitin interacting motif (UIM). We identified two substitutions relative… read more here.

Keywords: interacting motif; high affinity; affinity; dimerization ... See more keywords

Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer

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recommendations! Published in 2023 at "Protein Science"

DOI: 10.1002/pro.4599

Abstract: We report the discovery of the androgen receptor missense mutation V770D, that was found in two sisters suffering from complete androgen insensitivity. Experimental validation of AR V770 variants demonstrated that AR V770D was transcriptionally inactive… read more here.

Keywords: v770; lbd dimer; androgen receptor; dimerization ... See more keywords