Structural characterization of a dimerization interface in the CD28 transmembrane domain.
Sign Up to like & getrecommendations! Published in 2022 at "Structure"
DOI: 10.1016/j.str.2022.03.004
Abstract: CD28 has a crucial role in regulating immune responses by enhancing T cell activation and differentiation. Recent studies have shown that the transmembrane helix (TMH) of CD28 mediates receptor assembly and activity, but a structural characterization… read more here.
Keywords: structural characterization; cd28; dimerization interface; tmh ... See more keywords
Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0636-y
Abstract: RAS genes are the most commonly mutated oncogenes in human cancers. Despite tremendous efforts over the past several decades, however, RAS-specific inhibitors remain elusive. Thus, targeting RAS remains a highly sought-after goal of cancer research.… read more here.
Keywords: dimerization; targeting dimerization; dimerization interface; tumor formation ... See more keywords