Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability.
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DOI: 10.1021/acs.bioconjchem.2c00034
Abstract: Peptides are prime drug candidates due to their high specificity of action but are disadvantaged by low proteolytic stability. Here, we focus on the development of stabilized analogues of EPI-X4, an endogenous peptide antagonist of… read more here.
Keywords: cxcr4 antagonist; antagonist macromolecular; dimerization peptide; stability ... See more keywords