Synthesis, characterization and investigation of AChE and BuChE inhibitory activity of 1-alkyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium halide derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01804-1
Abstract: Abstract The design, synthesis and characterization of a series of 1-alkyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium halide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors for the treatment of Alzheimer’s disease were reported. The strategy for this synthesis was based on aldol… read more here.
Keywords: alkyl dimethoxy; buche; dimethoxy indanone; methylene ... See more keywords
Equilibrium Solubility Determination and Dissolution Property Analysis of 5,6-Dimethoxy-1-indanone in 15 Pure Solvents from 283.15 to 323.15 K
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DOI: 10.1021/acs.jced.1c00040
Abstract: The equilibrium solubility of 5,6-dimethoxy-1-indanone in 15 commonly used solvents, including methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, isobutyl alcohol, sec-butanol, n-amyl alc... read more here.
Keywords: solubility determination; equilibrium solubility; dimethoxy indanone;
A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation
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DOI: 10.3389/fnagi.2022.922650
Abstract: Backgrounds Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease. The treatment of AD through multiple pathological targets may generate therapeutic efficacy better. The multifunctional molecules that simultaneously hit several pathological targets have been of great… read more here.
Keywords: disease; alzheimer disease; ache; dimethoxy indanone ... See more keywords