Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists.
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DOI: 10.1021/acschemneuro.0c00129
Abstract: The 2,5-dimethoxyphenethylamine (2, 5-PEA) scaffold is recognized as a motif conferring potent agonist activity at the seroto-nin 2A receptor (5-HT2AR). The 2,5-dimethoxy motif is present in several classical phenethylamine psychedelics such as mesca-line, TMA-2, DOM,… read more here.
Keywords: phenethylamine; ht2ar; investigation dimethoxy; dimethoxy motif ... See more keywords