Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions
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DOI: 10.1016/j.jfluchem.2017.12.012
Abstract: Abstract Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported. read more here.
Keywords: ethylacetoacetate dimethyl; dimethyl fluoromalonate; fluoromalonate ester; component mannich ... See more keywords