Effect of Dimethyl Fumarate vs Interferon β-1a in Patients With Pediatric-Onset Multiple Sclerosis
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DOI: 10.1001/jamanetworkopen.2022.30439
Abstract: This randomized clinical trial investigates the efficacy and safety of dimethyl fumarate vs interferon β-1a for treatment of pediatric-onset multiple sclerosis. read more here.
Keywords: onset multiple; pediatric onset; multiple sclerosis; dimethyl fumarate ... See more keywords
Comparative Effectiveness of Rituximab and Other Initial Treatment Choices for Multiple Sclerosis
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DOI: 10.1001/jamaneurol.2017.4011
Abstract: Importance Comparative real-world effectiveness studies of initial disease-modifying treatment (DMT) choices for relapsing-remitting multiple sclerosis (RRMS) that include rituximab are lacking. Objective To assess the effectiveness and drug discontinuation rates of rituximab among patients with… read more here.
Keywords: dmts; initial treatment; treatment; discontinuation ... See more keywords
Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes
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DOI: 10.1002/acn3.676
Abstract: Identify metabolic changes produced by dimethyl fumarate (DMF) treatment and link them to immunological effects. read more here.
Keywords: induces lipid; lipid metabolism; treatment; treatment induces ... See more keywords
Natalizumab versus fingolimod and dimethyl fumarate in multiple sclerosis treatment
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.700
Abstract: To compare 2‐year effectiveness and discontinuation of natalizumab (NTZ) versus fingolimod (FTY) and dimethyl fumarate (DMF) in the treatment of multiple sclerosis (MS). read more here.
Keywords: treatment; versus fingolimod; multiple sclerosis; dimethyl fumarate ... See more keywords
Immunological predictors of dimethyl fumarate-induced lymphopenia.
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DOI: 10.1002/ana.26328
Abstract: OBJECTIVE Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. METHODS This prospective observational… read more here.
Keywords: dimethyl fumarate; induced lymphopenia; fumarate induced; predictors dimethyl ... See more keywords
Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome
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DOI: 10.1002/ana.26555
Abstract: The radiologically isolated syndrome (RIS) represents the earliest detectable pre‐clinical phase of multiple sclerosis (MS). This study evaluated the impact of therapeutic intervention in preventing first symptom manifestation at this stage in the disease spectrum. read more here.
Keywords: isolated syndrome; radiologically isolated; fumarate delays; multiple sclerosis ... See more keywords
Dimethyl fumarate protects thioacetamide‐induced liver damage in rats: Studies on Nrf2, NLRP3, and NF‐κB
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22476
Abstract: The present study was designed to investigate the hepatoprotective potential of dimethyl fumarate (DMF) against thioacetamide (TAA)‐induced liver damage. Wistar rats were treated with DMF (12.5, 25, and 50 mg/kg/day, orally) and TAA (200 mg/kg intraperitoneally, every… read more here.
Keywords: induced liver; liver damage; taa induced; dimethyl fumarate ... See more keywords
The deleterious effect of stress‐induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22627
Abstract: This study aimed to uncover the protective potentiality of resveratrol and dimethyl fumarate (DMF) in the liver of a chronic unpredictable mild stress (CUMS)‐induced depression animal model. Resveratrol and DMF significantly alleviated CUMS‐induced behavioral abnormalities… read more here.
Keywords: resveratrol; jnk; effect; resveratrol dimethyl ... See more keywords
Mechanism of action and therapeutic potential of dimethyl fumarate in ischemic stroke.
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DOI: 10.1002/jnr.25202
Abstract: Dimethyl fumarate (DMF) is an immunomodulatory drug currently approved for the treatment of multiple sclerosis and psoriasis. Its benefits on ischemic stroke outcomes have recently come to attention. To date, only tissue plasminogen activators (tPAs)… read more here.
Keywords: stroke; dimethyl fumarate; ischemic stroke; mechanism ... See more keywords
Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population-based cohort study
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2366-4
Abstract: PurposeTo describe patients initiating dimethyl fumarate (DMF) and measure persistence with DMF, discontinuation, and switching in treatment-naïve DMF patients and patients switching to DMF from other multiple sclerosis disease-modifying treatments (DMTs).MethodsA population-based cohort study of… read more here.
Keywords: treatment; study; dmf; multiple sclerosis ... See more keywords
Tolerability and safety of dimethyl fumarate in relapsing multiple sclerosis: a prospective observational multicenter study in a real-life Spanish population
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09848-7
Abstract: Background Dimethyl fumarate (DMF) tolerability and safety in multiple sclerosis (MS) has been analyzed in randomized clinical trials. Real-life studies are needed to assess possible harms of this therapy in a wider MS population. Objective… read more here.
Keywords: tolerability safety; safety; multiple sclerosis; real life ... See more keywords