Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO‐1 signaling pathway
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DOI: 10.1111/imcb.12316
Abstract: Dimethyl itaconate (DI) is a membrane‐permeable itaconate derivative with anti‐inflammatory functions. However, the anti‐inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI against… read more here.
Keywords: protects fungal; nrf2 signaling; dimethyl itaconate; fungal keratitis ... See more keywords
Dimethyl itaconate ameliorates the deficits of goal-directed behavior in Toxoplasma gondii infected mice
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011350
Abstract: Background The neurotrophic parasite Toxoplasma gondii (T. gondii) has been implicated as a risk factor for neurodegenerative diseases. However, there is only limited information concerning its underlying mechanism and therapeutic strategy. Here, we investigated the… read more here.
Keywords: goal directed; infection; gondii; mice ... See more keywords
Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.823285
Abstract: Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large population worldwide, with the fifth and seventh greatest mortality rates among men and women, respectively, and the third prime cause of mortality… read more here.
Keywords: hepatocellular carcinoma; preclinical evaluation; activation; dimethyl itaconate ... See more keywords
Dimethyl Itaconate Inhibits Melanogenesis in B16F10 Cells
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DOI: 10.3390/antiox12030692
Abstract: Itaconate is a metabolite produced to counteract and resolve pro-inflammatory responses when macrophages are challenged with intracellular or extracellular stimuli. In the present study, we have observed that dimethyl itaconate (DMI) inhibits melanogenesis in B16F10… read more here.
Keywords: b16f10 cells; melanogenesis b16f10; inhibits melanogenesis; dmi ... See more keywords
The Immunomodulator Dimethyl Itaconate Inhibits Several Key Steps of Angiogenesis in Cultured Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415972
Abstract: The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using… read more here.
Keywords: itaconate; endothelial cells; immunomodulator; key steps ... See more keywords