Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators
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DOI: 10.3390/molecules28062488
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor member of the protein tyrosine phosphatase (PTP) family, negatively regulates several signaling pathways that are responsible for pathological cell processes in cancers. In this… read more here.
Keywords: shp1 activators; dimethyl lithocholic; amino dimethyl; lithocholic acid ... See more keywords