Synthesis, characterization, and investigation of photochemical properties of tetra-substituted zinc phthalocyanines bearing 4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl moiety with different linker heteroatoms
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DOI: 10.1016/j.ica.2019.119306
Abstract: Abstract A novel 4-((3,5-dimethyl-1H-pyrazol-1-yl)phenylthio)phthalonitrile 3 and corresponding zinc phthalocyanine 5 has been synthesized and characterized. There has been investigated the effect of nature of the linker heteroatom (S or O) on spectroscopic, photophysical and photochemical… read more here.
Keywords: dimethyl pyrazol; zinc; photochemical properties; linker ... See more keywords
Synthesis, structure and biological activity of zinc(II) pincer complexes with 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine
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DOI: 10.1016/j.ica.2020.119627
Abstract: Abstract The reaction of 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) pincer ligand with Zn(NO3)2 and Zn(ClO4)2ยท6H2O/HCl yielded, [Zn(BPT)(NO3)2] (2), and [Zn(BPT)(H2O)Cl]ClO4 (3) complexes, respectively. However, zinc(II) chloride with BPT involved C N rupture and formed instead [Zn(DMP)2Cl2] (1) complex… read more here.
Keywords: pincer; methoxy triazine; dimethyl pyrazol; pyrazol methoxy ... See more keywords
N-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy.
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DOI: 10.1021/acsmedchemlett.6b00392
Abstract: Guided by antiproliferative activity in MIA PaCa-2 cells, we have performed preliminary structure-activity relationship studies on N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides. Two selected compounds showed submicromolar antiproliferative activity and good metabolic stability. Both compounds reduced mTORC1 activity and increased… read more here.
Keywords: dimethyl pyrazol; pyrazol benzamides; antiproliferative activity; activity ... See more keywords