Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0644-z
Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) exerts a critical role for ADMA degradation and plays an important role in NO signaling. In… read more here.
Keywords: plays important; dimethylarginine; ddah1; important role ... See more keywords
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2483-5
Abstract: The relationship of both asymmetric (ADMA) and symmetric (SDMA) dimethylarginine with carotid wall thickness is inconclusive especially among black populations. We aimed to compare carotid intima media thickness (cIMT) and dimethylarginine levels in 75 black… read more here.
Keywords: percentage change; dimethylarginine; black men; adma ... See more keywords
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-l-arginine, Nω,Nω-dimethyl-l-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-l-citrulline: results and overview
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2684-6
Abstract: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of nitric oxide (NO) synthase. SDMA is excreted in the urine without major metabolization. About 10% of daily produced ADMA are excreted unchanged in the… read more here.
Keywords: dimethylarginine; dimethyl; ddah activity; citrulline ... See more keywords
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust
Sign Up to like & getrecommendations! Published in 2018 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2018.1474976
Abstract: Abstract Objective: Workers exposed to dusts from concentrated animal feeding operations have a high prevalence of pulmonary diseases. These exposures lead to chronic inflammation and aberrant airway remodeling. Previous work shows that activating cAMP-dependent protein… read more here.
Keywords: epithelial cells; dimethylarginine; wound repair; airway epithelial ... See more keywords
S141 A novel dimethylarginine dimethylaminohydrolase 1 (DDAH1) genetic variant associated with lower asymmetric dimethylarginine (ADMA) levels predicts accelerated lung function decline and mortality in idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thorax-2018-212555.147
Abstract: Background Increased nitric oxide (NO) and its generating enzyme, inducible nitric oxide synthase (iNOS), are observed in experimental models of idiopathic pulmonary fibrosis (IPF). Asymmetric dimethylarginine (ADMA) competitively inhibits iNOS and is hydrolysed by dimethylarginine… read more here.
Keywords: dimethylarginine; fibrosis; ddah1; decline ... See more keywords
Decreased peripheral vascular function in patients with stage 3 and 4 chronic kidney disease who have elevated symmetric dimethylarginine but not asymmetric dimethylarginine
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734348
Abstract: Cardiovascular disease is a leading cause of death in chronic kidney disease (CKD), yet the mechanisms remain unclear. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous nitric oxide synthase inhibitors shown to be independent… read more here.
Keywords: function; dimethylarginine; ckd; patients stage ... See more keywords
Measurement of asymmetric dimethylarginine, nitric oxide levels and total antioxidant capacity in experimcntal diabetic rats
Sign Up to like & getrecommendations! Published in 2017 at "Medycyna Weterynaryjna"
DOI: 10.21521/mw.5741
Abstract: Diabetes is one of the systemic chronic metabolic diseases accompanied by hyperglycemia, dyslipidemia, glycosuria and much clinical and biochemical evidence (18). In diabetes, both acute and chronic complications can be seen in all organs. This… read more here.
Keywords: free radicals; dimethylarginine; dimethylarginine nitric; measurement asymmetric ... See more keywords
Asymmetric Dimethylarginine in an NMU-induced Rat Mammary Tumor Model
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DOI: 10.21873/anticanres.16138
Abstract: Background/Aim: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) production and a newly discovered risk factor involved in endothelial dysfunction and adverse cardiovascular events. Recently, both NO and ADMA have also emerged… read more here.
Keywords: dimethylarginine; asymmetric dimethylarginine; dimethylarginine nmu; sdma arginine ... See more keywords
Association of Asymmetric Dimethylarginine and Diastolic Dysfunction in Patients with Hypertrophic Cardiomyopathy
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DOI: 10.3390/biom9070277
Abstract: Despite genetic heterogeneity, early manifestation of diastolic dysfunction (DD) is common in hypertrophic cardiomyopathy (HCM). Nitric oxide (NO) may contribute to myocardial relaxation. NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine… read more here.
Keywords: dimethylarginine; hypertrophic cardiomyopathy; association; diastolic dysfunction ... See more keywords
Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030983
Abstract: Epigenetic readout of the combinatorial posttranslational modification comprised of trimethyllysine and asymmetric dimethylarginine (H3K4me3R8me2a) takes place via biomolecular recognition of tandem Tudor-domain-containing protein Spindlin1. Through comparative thermodynamic data and molecular dynamics simulations, we sought to… read more here.
Keywords: recognition; protein spindlin1; dimethylarginine; tandem tudor ... See more keywords