Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis
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DOI: 10.1126/sciadv.ade5584
Abstract: Osteoarthritis (OA) is a degenerative disease with a series of metabolic changes accompanied by many altered enzymes. Here, we report that the down-regulated dimethylarginine dimethylaminohydrolase-1 (DDAH1) is accompanied by increased asymmetric dimethylarginine (ADMA) in degenerated… read more here.
Keywords: sox9; asymmetric dimethylarginine; dimethylarginine adma; metabolite asymmetric ... See more keywords
Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis
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DOI: 10.2147/jir.s346575
Abstract: Objective The pathophysiological mechanisms of chronic pancreatitis (CP) still remain poorly understood. In this study, we aimed to characterize asymmetric dimethylarginine (ADMA)-containing proteins in pancreatic tissues and its relationship with CP pathogenesis. Methods Totally 36… read more here.
Keywords: dimethylarginine adma; adma; chronic pancreatitis; pathogenesis ... See more keywords
Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA)
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DOI: 10.3390/toxins9030092
Abstract: Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are toxic, non-proteinogenic amino acids formed by post-translational modification and are uremic toxins that inhibit nitric oxide (NO) production and play multifunctional roles in many human diseases.… read more here.
Keywords: dimethylarginine adma; adma; symmetric dimethylarginine; adma sdma ... See more keywords