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   Articles with "dimethylation" as a keyword



Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection

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recommendations! Published in 2019 at "Amino Acids"

DOI: 10.1007/s00726-019-02737-y

Abstract: The importance of l-arginine (Arg) and relatives, including l-homoarginine (hArg) and asymmetric dimethylarginine (ADMA), in humans infected with Helicobacter pylori (Hp) is little understood. ADMA is produced by asymmetric dimethylation of the guanidine group of… read more here.

Keywords: citrullination; arg; dimethylation; infection ... See more keywords

mNeuCode Empowers Targeted Proteome Analysis of Arginine Dimethylation.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c04648

Abstract: Characterization of protein arginine dimethylation presents significant challenges due to its occurrence at the substoichiometric level. To enable a targeted MS/MS analysis of these dimethylation sites, we developed the mNeuCode (methyl-neutron-coding) tag by metabolically labeling… read more here.

Keywords: targeted proteome; dimethylation; arginine dimethylation; proteome analysis ... See more keywords

Improved discrimination of asymmetric and symmetric arginine dimethylation by optimization of the normalized collision energy in LC-MS proteomics.

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recommendations! Published in 2020 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.0c00116

Abstract: Protein arginine methylation regulates diverse biological processes including signaling, metabolism, splicing, and transcription. Despite its important biological roles, arginine dimethylation remains an understudied post-translational modification. Partly, this is because the two forms of arginine dimethylation,… read more here.

Keywords: arginine dimethylation; dimethylation; collision energy; normalized collision ... See more keywords

Loss of NSD2 causes dysregulation of synaptic genes and altered H3K36 dimethylation in mice

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recommendations! Published in 2024 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2024.1308234

Abstract: Background: Epigenetic disruptions have been implicated in neurodevelopmental disorders. NSD2 is associated with developmental delay/intellectual disability; however, its role in brain development and function remains unclear. Methods: We performed transcriptomic and epigenetic analyses using Nsd2… read more here.

Keywords: mice; dimethylation; dysregulation; loss nsd2 ... See more keywords