Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria
Sign Up to like & getrecommendations! Published in 2019 at "Tropical Animal Health and Production"
DOI: 10.1007/s11250-019-01902-5
Abstract: African animal trypanosomiasis is a major cause of mortality and economic losses for the livestock industry in Nigeria. Chemotherapy has been the most reliable option for cattle herders, and the most commonly found drug on… read more here.
Keywords: resistance trypanosoma; trypanosoma species; diminazene aceturate; suspected resistance ... See more keywords
Anti-diarrheal therapeutic potential of Diminazene Aceturate stimulation of the ACE II/Ang-(1-7)/Mas receptor axis in mice: a trial study.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114500
Abstract: The angiotensin (Ang) II converting enzyme (ACE II) pathway has recently been shown to be associated with several beneficial effects on the body, especially on the cardiac system and gastrointestinal tract. ACE II is responsible… read more here.
Keywords: mas receptor; diminazene aceturate; ang; ace ... See more keywords
ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.07.008
Abstract: Abstract The obesity epidemic is multi‐generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions. Recent evidence suggests that increasing the activity of the angiotensin converting enzyme‐2 [ACE2]/angiotensin‐(1‐7)[Ang‐(1‐7)]/Mas receptor (MasR)… read more here.
Keywords: diminazene aceturate; mass; rats fed; body weight ... See more keywords
Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117749
Abstract: AIM This work aims to explore the role of diminazene aceturate (DIZE) in the enhancement of angiotensin-converting enzyme-2 (ACE2) to prevent the inflammatory and fibrotic response induced by γ-irradiation through activating the protective axis ACE2/angiotensin… read more here.
Keywords: renal deleterious; irradiation; diminazene aceturate; ace2 ... See more keywords
Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2022.170746
Abstract: This study aimed to investigate whether the Diminazene Aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, can revert cardiac dysfunction in ischemia reperfusion-induced (I/R) injury in animals and examine the mechanism underlying this effect. Wistar… read more here.
Keywords: injury; diminazene aceturate; enzyme ace2; angiotensin converting ... See more keywords
Azithromycin and Diminazene Aceturate Combination Therapy in Experimental Multidrug-resistant Trypanosoma brucei brucei Infection in Albino Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2020.109138
Abstract: Azithromycin and diminazene aceturate combination therapy in experimental multidrug-resistant Trypanosoma brucei brucei infection in albino rats was evaluated. A total of forty-five female albino rats were used. These rats were randomly assigned to nine groups… read more here.
Keywords: combination; diminazene aceturate; group; brucei ... See more keywords
Repurposing streptomycin and chloramphenicol against bacterial pathogens by combination with diminazene aceturate.
Sign Up to like & getrecommendations! Published in 2023 at "Letters in applied microbiology"
DOI: 10.1093/lambio/ovac009
Abstract: Bacterial resistance is a threat to health worldwide, mainly due to reduced effective treatment. In this context, the search for strategies to control such infections and suppress antimicrobial resistance is necessary. One of the strategies… read more here.
Keywords: chloramphenicol bacterial; combination; repurposing streptomycin; diminazene aceturate ... See more keywords
Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Complementary and Integrative Medicine"
DOI: 10.1515/jcim-2020-0451
Abstract: Abstract Objectives This study demonstrated the enhancing actions of probiotic on the antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei. Methods Twenty (20) apparently healthy adult local dogs of both… read more here.
Keywords: effects diminazene; group; aceturate dogs; antitrypanosomal effects ... See more keywords
Synthesis and Characterization of Inclusion Complex of Diminazene Aceturate with b-Ciclodextrin
Sign Up to like & getrecommendations! Published in 2019 at "Revista de Chimie"
DOI: 10.37358/rc.19.6.7291
Abstract: Cyclodextrins (CD) are macrocyclic biopolymers with potential applications in the delivery of small and macro-molecular therapeutic agents. Despite the potent host-guest inclusion property, their inherent lack of cellular binding ability has limited applications in drug… read more here.
Keywords: inclusion; inclusion complex; diminazene aceturate; synthesis characterization ... See more keywords