Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.
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DOI: 10.1021/acs.jmedchem.2c00118
Abstract: d-Serine is a coagonist of the N-methyl d-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. In the brain, d-serine is synthesized from its l-isomer by serine racemase and is metabolized by the D-amino acid oxidase… read more here.
Keywords: class; acid oxidase; amino acid; dinger computational ... See more keywords