Kinetic regularities of NO donation by binuclear dinitrosyl iron complexes with thiolate ligands based on thiophenol derivatives in the presence of red blood cells
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2989-y
Abstract: The kinetics of nitrogen oxide release by binuclear dinitrosyl iron complexes (B-DNICs) with thiolate ligands based on thiophenol and its several oxy, amino, and nitro derivatives was studied using a suspension of red blood cells… read more here.
Keywords: red blood; donation; dinitrosyl iron; blood ... See more keywords
LDL dinitrosyl iron complex acts as an iron donor in mouse macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.08.004
Abstract: [Fe(NO)2] - modified nanoparticles of low-density protein (DNICLDL) can serve as conveyors of iron in the form of stable complexes with ApoB100 protein. As reported recently, in human hepatoma cells DNICLDL significantly increased the total… read more here.
Keywords: iron complex; acts iron; ldl dinitrosyl; dinitrosyl iron ... See more keywords
Effects of Glutathione and Histidine on NO Release from a Dimeric Dinitrosyl Iron Complex (DNIC).
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c02196
Abstract: Rates of NO release from synthetic dinitrosyl iron complexes (DNICs) are shown to be responsive to coordination environments about iron. The effect of biologically relevant cellular components, glutathione and histidine, on the rate of NO… read more here.
Keywords: dinitrosyl iron; release dimeric; glutathione histidine; release ... See more keywords
Toward the Optimization of Dinitrosyl Iron Complexes as Therapeutics for Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00389
Abstract: In this study, dinitrosyl iron complexes (DNICs) are shown to deliver nitric oxide (NO) into the cytosol of vascular smooth muscle cells (SMCs), which play a major role in vascular relaxation and contraction. Malfunction of… read more here.
Keywords: muscle cells; smooth muscle; iron complexes; dinitrosyl iron ... See more keywords
Distortion of the [FeNO]2 Core in Flavodiiron Nitric Oxide Reductase Models Inhibits N-N Bond Formation and Promotes Formation of Unusual Dinitrosyl Iron Complexes: Implications for Catalysis and Reactivity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10388
Abstract: Flavodiiron nitric oxide reductases (FNORs) carry out the reduction of nitric oxide (NO) to nitrous oxide (N2O), allowing infectious pathogens to mitigate toxic levels of NO generated in the human immune response. We previously reported… read more here.
Keywords: core; dinitrosyl iron; nitric oxide; flavodiiron nitric ... See more keywords
Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03103a
Abstract: By repurposing DNICs designed for other medicinal purposes, the possibility of protease inhibition was investigated in silico using AutoDock 4.2.6 (AD4) and in vitro via a FRET protease assay. AD4 was validated as a predictive… read more here.
Keywords: protease; inhibition; cov main; main protease ... See more keywords
Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672918060133
Abstract: The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency… read more here.
Keywords: effect; effect dinitrosyl; dinitrosyl iron; iron complexes ... See more keywords
Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells
Sign Up to like & getrecommendations! Published in 2019 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672919030190
Abstract: The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7… read more here.
Keywords: multiple myeloma; myeloma cells; iron complex; dinitrosyl iron ... See more keywords
Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221810101
Abstract: After the discovery of endogenous dinitrosyl iron complexes (DNICs) as a potential biological equivalent of nitric oxide (NO), bioinorganic engineering of [Fe(NO)2] unit has emerged to develop biomimetic DNICs [(NO)2Fe(L)2] as a chemical biology tool… read more here.
Keywords: delivery; dermato physiological; cell penetrating; dinitrosyl iron ... See more keywords