Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25474
Abstract: Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to antiseizure drugs, with effective drug development impeded by lack of understanding on how seizures are initiated. Here, we report the mechanism of seizure… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; dinucleotide phosphate; phosphate oxidase ... See more keywords
Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000406
Abstract: Previous research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to… read more here.
Keywords: phosphate diaphorase; tolerance; dinucleotide phosphate; nitric oxide ... See more keywords
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox subunit polymorphisms, systemic oxidative stress, endothelial dysfunction, and atherosclerosis in type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2021 at "Polish archives of internal medicine"
DOI: 10.20452/pamw.15937
Abstract: INTRODUCTION Diabetes mellitus is an important and rapidly increasing problem in public health. It associates with endothelial dysfunction and increased endothelial permeability, which may lead to severe cardiovascular events. OBJECTIVES We aimed to evaluate the… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; dysfunction; dinucleotide phosphate ... See more keywords
Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models
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DOI: 10.3390/antiox10020218
Abstract: Alzheimer’s disease (AD) is one of the main human dementias around the world which is constantly increasing every year due to several factors (age, genetics, environment, etc.) and there are no prevention or treatment options… read more here.
Keywords: adenine dinucleotide; oxidase; nicotinamide adenine; alzheimer disease ... See more keywords
Roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase in Angiogenesis: Isoform-Specific Effects
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DOI: 10.3390/antiox6020040
Abstract: Angiogenesis is the formation of new blood vessels from preexisting ones and is implicated in physiologic vascular development, pathologic blood vessel growth, and vascular restoration. This is in contrast to vasculogenesis, which is de novo… read more here.
Keywords: adenine dinucleotide; phosphate nadph; nicotinamide adenine; angiogenesis ... See more keywords
Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke
Sign Up to like & getrecommendations! Published in 2019 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.250568
Abstract: Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a multisubunit enzyme complex that utilizes nicotinamide adenine dinucleotide phosphate to produce superoxide anions and other reactive oxygen species. Under normal circumstances, reactive oxygen species mediate a number… read more here.
Keywords: adenine dinucleotide; ischemic stroke; nicotinamide adenine; dinucleotide phosphate ... See more keywords