Impaired soft and hard callus formation during fracture healing in diet-induced obese mice as revealed by 3D contrast-enhanced computed tomography imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116008
Abstract: The impact of diabetes mellitus on bone fracture healing is clinically relevant as the patients experience delayed fracture healing. Even though efforts have been made to understand the detrimental effects of type 2 diabetes mellitus… read more here.
Keywords: fracture; diet induced; fracture healing; induced obese ... See more keywords
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.12.001
Abstract: Objective Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods A series of peptide-based GIP analogs, including structurally diverse agonists and a… read more here.
Keywords: weight lowering; gipr; mice; body weight ... See more keywords
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-03670-5
Abstract: Treatment with a nicotinamide N-methyltransferase inhibitor (NNMTi; 5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD… read more here.
Keywords: age matched; mice; dio mice; distinct microbiome ... See more keywords
SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-12320-z
Abstract: Hypertension, diabetes, and obesity are comorbidities that influence severe cases of COVID-19 and are associated with weak humoral immunity after vaccination. We hypothesized that the diet-induced obese (DIO) K18-hACE2 mouse model could be utilized to… read more here.
Keywords: sars cov; dio; dio mice; cell ... See more keywords
Abstract LB343: Antitumor and metabolomic evaluation of immune checkpoint inhibition in diet-induced obese mice
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb343
Abstract: Obesity is an epidemic in the Western world and a risk factor for at least 13 types of cancer. Cancer rates are rising for several obesity-related cancers, such as liver, pancreatic, thyroid, and uterine, as… read more here.
Keywords: growth; mice; dio mice; tumor ... See more keywords
Abstract 02: Time restricted feeding reduces kidney fibrosis in diet-induced obesity through limiting kidney CD8+ T cell infiltration
Sign Up to like & getrecommendations! Published in 2024 at "Hypertension"
DOI: 10.1161/hyp.81.suppl_1.02
Abstract: Obesity is a leading cause of chronic kidney disease (CKD). Our lab previously showed that a 20 week diet-induced obesity (DIO) protocol (45% high fat) significantly increased kidney medullary fibrosis in male mice. Further, we… read more here.
Keywords: cd8 cells; cd8; dio; dio mice ... See more keywords
Identification and Characterization of a Novel Insulin Sensitizer to Treat Diabetes and Nonalcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-237-lb
Abstract: Thiazolidinediones (TZDs) enhance insulin sensitivity and have efficacy for treating nonalcoholic steatohepatitis (NASH). However, the use of TZDs, like rosiglitazone and pioglitazone, has been curtailed by significant side effects mediated via the peroxisome proliferator-activated receptor… read more here.
Keywords: insulin; msdc 5514; insulin sensitizer; nonalcoholic steatohepatitis ... See more keywords
1694-P: De Novo or Sequential Combination of the Mitochondrial Protonophore TLC-1180 with Semaglutide Improves Weight Loss and Preserves Lean Mass in Dio Mice
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-1694-p
Abstract: Introduction and Objective: TLC-1180 is a novel, potent mitochondrial protonophore with extended pharmacology. Here, we evaluated ‘1180 as monotherapy (mono), in combination (combo) with semaglutide (SEMA), and for maintenance post SEMA discontinuation (D/C) in diet-induced… read more here.
Keywords: employee orsobio; inc; dio mice; orsobio inc ... See more keywords
1715-P: Discovery of a Novel Long-Acting Urocortin 2 Analog for Improving Body Composition in Obese Mice
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-1715-p
Abstract: Introduction and Objective: Urocortin 2 (UCN2) has been shown to reduce fat mass and increase muscle mass. While GLP-1-based therapies have demonstrated significant weight loss, they may lead to muscle mass reduction with long-term use.… read more here.
Keywords: analog; body; body composition; dio mice ... See more keywords
Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.795371
Abstract: High-calorie intake has become one of the most common causes of dietary obesity, which eventually develops into type 2 diabetes mellitus (T2DM). Microbiota, along with the length of the gastrointestinal tract, is related to metabolic… read more here.
Keywords: microbiota; gut microbiota; diet induced; obesity ... See more keywords
Glucose- and Bile Acid-Stimulated Secretion of Gut Hormones in the Isolated Perfused Intestine Is Not Impaired in Diet-Induced Obese Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.884501
Abstract: Purpose Decreased circulating levels of food-intake-regulating gut hormones have been observed in type 2 diabetes and obesity. However, it is still unknown if this is due to decreased secretion from the gut mucosal cells or… read more here.
Keywords: glucose bile; dio mice; secretion; gut hormones ... See more keywords