Targeting the DIO3 enzyme using first-in-class inhibitors effectively suppresses tumor growth: a new paradigm in ovarian cancer treatment
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02020-z
Abstract: The enzyme iodothyronine deiodinase type 3 (DIO3) contributes to cancer proliferation by inactivating the tumor-suppressive actions of thyroid hormone (T3). We recently established DIO3 involvement in the progression of high-grade serous ovarian cancer (HGSOC). Here… read more here.
Keywords: dio3; paradigm ovarian; ovarian cancer; dio3 enzyme ... See more keywords
Low Type 3 Deiodinase (DIO3) activity Post-Myocardial Infarction leads to a Greater Incidence of Heart Failure in Female Mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5725688
Abstract: Objective: Studies in male mice show that myocardial infarction (MI) leads to the upregulation of type 3 deiodinase (DIO3), the enzyme that inactivates thyroid hormones, which has been regarded as a predictor of poor outcomes… read more here.
Keywords: dio3; dio3 activity; physiology; heart ... See more keywords
DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities
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DOI: 10.1172/jci.insight.161214
Abstract: Maternal hyperthyroidism is associated with an increased incidence of congenital abnormalities at birth, but it is not clear which of these defects arise from a transient developmental excess of thyroid hormone and which depend on… read more here.
Keywords: cranio encephalic; dio3; thyrotoxicosis; congenital abnormalities ... See more keywords
OR10-4 Spermatogonial Type 3 Deiodinase Regulates Thyroid Hormone Action in Developing Testicular Somatic Cells
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DOI: 10.1210/js.2019-or10-4
Abstract: Abstract The influence of thyroid hormone (TH) on male reproduction is not well understood. Male mice lacking the type 3 deiodinase (DIO3), which inactivates TH, exhibit deficits in testis growth, reproductive hormone levels, spermatogenesis and… read more here.
Keywords: expression; testis; regulated genes; cell ... See more keywords