New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200023
Abstract: 1‐Methyl/ethyl/benzyl‐5‐(un)substituted 1H‐indole‐2,3‐diones (2, 3, and 4) were synthesized by reaction of 5‐(un)substituted 1H‐indole‐2,3‐diones (1) with methyl iodide, ethyl chloride, and benzyl bromide. (3‐Sulfamoylphenyl)isothiocyanate (6) was obtained by the treatment of 3‐aminobenzenesulfonamide (5) with thiophosgene. Compound… read more here.
Keywords: substituted indole; thiosemicarbazones sulfamoylphenyl; new indole; dione ... See more keywords
Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700539
Abstract: A new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal… read more here.
Keywords: pyrrolidine dione; dione; lipophilicity; dione derivatives ... See more keywords
An Efficient Synthesis of 6′‐methyl‐1'H‐spiro[indoline‐3,4′‐pyrimidine]‐2,2′(3'H)‐dione Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2944
Abstract: The reactions of isatins, urea and 1-(piperidin-1-yl)butane-1,3-dione or 1-morpholinobutane-1,3-dione have been developed for the preparation of spiroheterocycles compounds. It was found these reactions could be given higher yields and required shorter time in our process.… read more here.
Keywords: dione; efficient synthesis; methyl spiro; spiro indoline ... See more keywords
Oxygenated polycyclic aromatic hydrocarbons in mussels: analytical method development and occurrence in the Belgian coastal zone
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-04259-2
Abstract: An analytical method was developed for the trace quantification of oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) in mussels. Compounds included were naphthalene-1-ol, 9H-fluoren-9-one, anthracene-9,10-dione, 7H-benz[de]anthracene-7-one, naphtacene-5,12-dione, and benzo[a]anthracene-7,12-dione. Pyrene-1-carboxaldehyde was applied as an internal standard. Sample… read more here.
Keywords: analytical method; dione; method; aromatic hydrocarbons ... See more keywords
Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103128
Abstract: α-Glucosidase is considered as a therapeutic target for the treatment of type 2 diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit α-Glucosidase. Pyrrolidine-2,5-dione… read more here.
Keywords: pyrrolidine dione; dione; thiazolidine dione; dione derivatives ... See more keywords
Occurrence, fate and risk assessment of androgens in ten wastewater treatment plants and receiving rivers of South China.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.02.144
Abstract: Androgens are one class of steroids that could cause endocrine disrupting effects in aquatic organisms. However, little information is available about androgens in wastewater treatment plants (WWTPs) with different treatment technologies. Here we investigated the… read more here.
Keywords: risk; dione; removal; wastewater treatment ... See more keywords
1,2,4-Triazoline-3,5-dione substituted perylene diimides as near infrared acceptors for bulk heterojunction organic solar cells
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.109108
Abstract: Abstract A series of perylene diimide derivatives (PDIs) with near infrared (NIR) absorption and different geometries were synthesized by introducing 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) and 4-butyl-1,2,4-triazoline-3,5-dione (BuTAD) to the bay position of PDIs through the Diels–Alder reaction.… read more here.
Keywords: organic solar; triazoline dione; dione; bulk heterojunction ... See more keywords
The gravity field and interior structure of Dione
Sign Up to like & getrecommendations! Published in 2020 at "Icarus"
DOI: 10.1016/j.icarus.2020.113713
Abstract: Abstract During its mission in the Saturn system, Cassini performed five close flybys of Dione. During three of them, radio tracking data were collected during the closest approach, allowing estimation of the full degree-2 gravity… read more here.
Keywords: topography; dione; field interior; gravity ... See more keywords
Saturn’s icy satellites investigated by Cassini - VIMS. V. Spectrophotometry
Sign Up to like & getrecommendations! Published in 2021 at "Icarus"
DOI: 10.1016/j.icarus.2021.114803
Abstract: Albedo, spectral slopes, and water ice band depths maps for the five midsized saturnian satellites Mimas, Enceladus, Tethys, Dione, and Rhea have been derived from Cassini-Visual and Infrared Mapping Spectrometer (VIMS) data. The maps are… read more here.
Keywords: tethys; dione; cassini; band ... See more keywords
5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study
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DOI: 10.1016/j.molstruc.2020.127982
Abstract: Abstract An environmental friendly heterogeneous catalyst Cell-CuI-NPs was employed for the synthesis of biologically promising 1-((1-aryl)-1H-1,2,3-triazol-4-yl)methyl-5-fluoroindoline-2,3-diones via CuAAC click reaction of 5-fluoro-(1-prop-2-ynyl)indoline-2,3-dione, an alkyne with various organic azides in aqueous medium. Compounds 4b, and 4c,… read more here.
Keywords: potency; dione; dft study; mol ... See more keywords
Regioselectivity evaluation of the (Z)-5-(4-hydroxybenzylidene)-thiazolidine-2,4‑dione alkylation in alkaline environment
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130629
Abstract: Abstract Thiazolidine-2,4‑dione represents a key heterocyclic core in medicinal chemistry because it has the ability to bind to a wide variety of protein targets and has been intensively studied for developing bioactive multitargeting agents. The… read more here.
Keywords: dione; alkylation; thiazolidine dione; hydroxybenzylidene thiazolidine ... See more keywords