Lipase mediated multicomponent synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in binary solvent medium.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2264
Abstract: A new method for the synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from Aspergillus niger (ANL) catalyzed multicomponent reaction of aldehydes, malononitrile, and phthalhydrazide is reported herein for the first time. This novel method holds several… read more here.
Keywords: phthalazine dione; synthesis pyrazolo; lipase; dione derivatives ... See more keywords
Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
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DOI: 10.1002/cmdc.201700539
Abstract: A new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal… read more here.
Keywords: pyrrolidine dione; dione; lipophilicity; dione derivatives ... See more keywords
Synthesis and Computational Studies on Optoelectronically Important Novel Acridin-Isoindoline-1,3-Dione Derivatives
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DOI: 10.1007/s10895-019-02376-2
Abstract: A series of novel 2-(4-(acridin-9-ylamino)phenyl)isoindoline-1,3-dione derivatives were designed and synthesized namely 2-(4-(4-methoxyacridin-9-ylamino)phenyl)isoindoline-1,3-dione [S1], 2-(4-(3-chloroacridin-9ylamino)phenyl)isoindoline-1,3-dione [S2], 2-(4-(2-fluor oacridin-9ylamino)phenyl)isoindoline-1,3-dione [S3], 2-(4-(1,4-dichloroacridin-9ylamino) phenyl)isoindoline-1,3-dione [S4]. The photophysical, thermal properties of these compounds were characterized by the spectroscopic and thermographic… read more here.
Keywords: novel acridin; isoindoline dione; phenyl isoindoline; dione derivatives ... See more keywords
Design, synthesis, biological evaluation and molecular dynamics simulation studies of imidazolidine-2,4-dione derivatives as novel PTP1B inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.047
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood… read more here.
Keywords: molecular dynamics; imidazolidine dione; dione derivatives; dynamics simulation ... See more keywords
Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103128
Abstract: α-Glucosidase is considered as a therapeutic target for the treatment of type 2 diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit α-Glucosidase. Pyrrolidine-2,5-dione… read more here.
Keywords: pyrrolidine dione; dione; thiazolidine dione; dione derivatives ... See more keywords
Cholinesterases, α-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer's disease and diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103647
Abstract: In this study, using the Cu(OTf)2 catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and… read more here.
Keywords: phthalazine dione; pyrazolo phthalazine; carbonic anhydrase; dione derivatives ... See more keywords
Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme.
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DOI: 10.1016/j.bioorg.2020.104059
Abstract: Novel series of 5-benzylidenethiazolidine-2,4-dione derivatives 4a-c-8a-f were designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell lines. MCF-7 was the most sensitive cell line to the influence of the new derivatives.… read more here.
Keywords: benzylidenethiazolidine dione; dione derivatives; anticancer; cell ... See more keywords
Application of cyclohexane-1,3-diones for six-membered oxygen-containing heterocycles synthesis.
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DOI: 10.1016/j.bioorg.2020.104559
Abstract: Cyclohexan-1,3-dione derivatives are versatile scaffolds for the synthesis of a variety of value-added organic molecules including heterocycles and natural products. Six-membered oxygen heterocycles prepared from cyclohexan-1,3-diones are of much importance as they are intermediate for… read more here.
Keywords: dione derivatives; membered oxygen; six membered; chemistry ... See more keywords
Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives
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DOI: 10.1016/j.heliyon.2018.e00807
Abstract: Abstract Various thiazolidine-2,4-dione derivatives 3a-l possessing indole moiety were designed, synthesized using appropriate conventional heating as well as microwave irradiation methods. All the synthesized compounds were characterized physically and spectrally. The compounds were evaluated for… read more here.
Keywords: docking studies; thiazolidine dione; dione derivatives; activity ... See more keywords
New route to synthesis of unexpected 1,5-bis(1-benzofuran-2-yl) pentane-1,5-dione derivatives: Their structure determination with spectroscopic and X-ray methods
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.10.063
Abstract: Abstract The new 1,5-bis(1-benzofuran-2-yl)-1,5-dione derivatives were obtained by the reaction of 2-acetyl benzofuran derivatives (1a–b) and suitable aromatic aldehyde derivatives (2-pyridinecarboxaldehyde, 2-fluoro and 3-fluorobenzaldehyde) in the presence of sodium hydroxide as the base. Importantly, a… read more here.
Keywords: bis benzofuran; ray; dione derivatives; benzofuran ... See more keywords
Wang-OSO3H catalyzed green synthesis of bioactive isoindolo[2,1-a]quinazoline-5,11-dione derivatives: An unexpected observation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131922
Abstract: ABSTRACT The sulphonic acid-functionalized Wang resin (Wang-OSO3H) was explored as a polymeric and recoverable acidic catalyst for the synthesis of isoindolo[2,1-a]quinazoline-5,11-dione derivatives under green conditions. Thus the Wang-OSO3H catalyzed MCR of isatoic anhydride, 2-formylbenzoic acid… read more here.
Keywords: oso3h catalyzed; wang oso3h; isoindolo quinazoline; quinazoline dione ... See more keywords