Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.
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DOI: 10.1016/j.ejmech.2017.06.040
Abstract: Alzheimer's disease is characterized by chronic neurodegeneration leading to dementia. The main cause of neurodegeneration is considered to be the accumulation of amyloid-β. Inhibiting BACE1 is a well-studied approach to lower the burden of amyloid-β… read more here.
Keywords: dione framework; isoindoline dione; imidazopyridines containing; containing isoindoline ... See more keywords