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   Articles with "diosgenin" as a keyword



Oral administration with diosgenin enhances the induction of intestinal T helper 1‐like regulatory T cells in a murine model of food allergy

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2016.11.021

Abstract: Abstract Although the development of T helper (Th)1‐like regulatory T (Treg) cells under Th1 inflammatory conditions has been reported, the role of Th1‐like Treg cells in Th2 allergic responses remains mostly unclear. We previously demonstrated… read more here.

Keywords: like treg; treg cells; th1 like; diosgenin ... See more keywords

A synthetic diosgenin primary amine derivative attenuates LPS‐stimulated inflammation via inhibition of NF‐&kgr;B and JNK MAPK signaling in microglial BV2 cells

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.05.021

Abstract: &NA; Diosgenin, a precursor of steroid hormones in plants, is known to exhibit diverse pharmacological activities including anti‐inflammatory properties. In this study, (3&bgr;, 25R)‐spirost‐5‐en‐3‐oxyl (2‐((2((2‐aminoethyl)amino)ethyl)amino)ethyl) carbamate (DGP), a new synthetic diosgenin derivative incorporating primary amine… read more here.

Keywords: jnk; lps stimulated; diosgenin; bv2 cells ... See more keywords
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Dioscin and diosgenin: insights into their potential protective effects in cardiac diseases.

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recommendations! Published in 2021 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2021.114018

Abstract: BACKGROUND AND ETHNOPHARMACOLOGICAL RELEVANCE Dioscin and diosgenin derived from plants of the genus Dioscoreaceae such as D. nipponica and D. panthaica Prain et Burk. Were utilized as the main active ingredients of traditional herbal medicinal… read more here.

Keywords: research; diosgenin insights; diosgenin; dioscin diosgenin ... See more keywords

Biosynthetic Gene Expression and Tissue Distribution of Diosgenin in Dioscorea japonica.

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recommendations! Published in 2023 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c08478

Abstract: Diosgenin is an aglycone of dioscin, a major bioactive steroidal saponin found in plants, including Himalayan Paris (Paris polyphylla), fenugreek (Trigonella foenum-graecum), and yam (Dioscorea spp.). We have previously demonstrated that a species of natural… read more here.

Keywords: diosgenin; japonica; japonica bulbils; dioscorea japonica ... See more keywords

Design, synthesis and biological evaluation of novel diosgenin–benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells

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recommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2022.2070161

Abstract: Abstract To discover new lead compounds with anti-tumour activities, in the present study, natural diosgenin was hybridised with the reported benzoic acid mustard pharmacophore. The in vitro cytotoxicity of the resulting newly synthesised hybrids (8–10,… read more here.

Keywords: diosgenin; benzoic acid; acid mustard; hepg2 cells ... See more keywords

The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins

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recommendations! Published in 2022 at "Horticulture Research"

DOI: 10.1093/hr/uhac165

Abstract: Abstract Diosgenin saponins isolated from Dioscorea species such as D. zingiberensis exhibit a broad spectrum of pharmacological activities. Diosgenin, the aglycone of diosgenin saponins, is an important starting material for the production of steroidal drugs.… read more here.

Keywords: zingiberensis; origin evolution; diosgenin; dioscorea species ... See more keywords

Genome-wide methylation, transcriptome and characteristic metabolites reveal the balance between diosgenin and brassinosteroids in Dioscorea zingiberensis

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recommendations! Published in 2024 at "Horticulture Research"

DOI: 10.1093/hr/uhae056

Abstract: Abstract Diosgenin (DG) is a bioactive metabolite isolated from Dioscorea species, renowned for its medicinal properties. Brassinosteroids (BRs) are a class of crucial plant steroidal hormones. Cholesterol and campesterol are important intermediates of DG and… read more here.

Keywords: transcriptome characteristic; genome wide; methylation transcriptome; zingiberensis ... See more keywords

Diosgenin: An ingress towards solving puzzle for diabetes treatment.

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recommendations! Published in 2022 at "Journal of food biochemistry"

DOI: 10.1111/jfbc.14390

Abstract: The consumption and composition of food in daily life predict our health in long run. The relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin regulation in the human body… read more here.

Keywords: diabetes treatment; diosgenin; ingress towards; diosgenin ingress ... See more keywords

Reprogramming of Diosgenin-Specialized Metabolism in Plants and Its Medicinal Applications.

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recommendations! Published in 2025 at "Physiologia plantarum"

DOI: 10.1111/ppl.70621

Abstract: Diosgenin, a steroidal sapogenin abundantly present in Dioscorea species, is widely recognized for its therapeutic attributes, including anticancer, antidiabetic, anti‐inflammatory, antioxidant, antiviral, and anti‐thrombotic activities. Its implication in addressing a broad spectrum of genetic and… read more here.

Keywords: specialized metabolism; diosgenin specialized; reprogramming diosgenin; diosgenin ... See more keywords

Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/4849464

Abstract: Results When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to… read more here.

Keywords: extract; diosgenin; inhibitory effect; effect ... See more keywords

Diosgenin improves functional recovery from sciatic crushed nerve injury in rats

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recommendations! Published in 2018 at "Journal of Exercise Rehabilitation"

DOI: 10.12965/jer.1836340.170

Abstract: Peripheral nerve injuries are commonly encountered clinical problem and often result in chronic pain and severe functional deficit. Diosgenin is a plant steroidal saponin and has anti-inflammatory and anticancer effects. In the present study, we… read more here.

Keywords: diosgenin; functional recovery; nerve injury; injury ... See more keywords