Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23774
Abstract: Flavonoids, constituting the most extensive category of polyphenols, founds in a variety of plants and comprise over 9000 compounds. Diosmetin, O‐methylated flavone (3’,5,7‐trihydroxy‐4’‐methoxyflavone) of flavonoid aglycone diosmin have witnessed a significant surge in recent years.… read more here.
Keywords: cancer; diosmetin; diosmetin dietary; progression ... See more keywords
Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23504
Abstract: Diosmetin was found to exert protective effect on renal and myocardial ischemia‐reperfusion (IR) injury. This study aimed to investigate the role of diosmetin in cerebral IR (CIR) injury. PC12 neurons were exposed to oxygen–glucose deprivation/reoxygenation… read more here.
Keywords: inhibition; diosmetin; keap1; injury ... See more keywords
Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis model
Sign Up to like & getrecommendations! Published in 2020 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2020.107046
Abstract: Diosmetin, a citrus flavonoid, has a variety of therapeutic properties such as antibacterial, anti-inflammatory and antioxidant effects. However, the effect of diosmetin on atopic dermatitis (AD) development has not been reported. This study thus aims… read more here.
Keywords: diosmetin; atopic dermatitis; lps induced; anti inflammatory ... See more keywords
Diosmetin Alleviates Cerebral Ischemia/Reperfusion Injury by Modulating Tryptophan Metabolism through the Microbiota-Gut-Brain Axis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c08004
Abstract: Cerebral ischemia-reperfusion (I/R) injury involves brain tissue damage caused by a temporary interruption of blood flow followed by reperfusion, leading to inflammation, oxidative stress, and neuronal death. Diosmetin, a flavonoid with known anti-inflammatory and antioxidant… read more here.
Keywords: diosmetin; brain; microbiota gut; injury ... See more keywords
Estrogen Receptor β Is a Novel Target in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0292
Abstract: Acute myeloid leukemia (AML) is a devastating disease characterized by poor patient outcome and suboptimal chemotherapeutics. Here, a high-throughput screen identified diosmetin, a citrus flavonoid, with anti-AML activity. Diosmetin imparted selective toxicity against leukemia and… read more here.
Keywords: estrogen receptor; myeloid leukemia; diosmetin; acute myeloid ... See more keywords
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15413
Abstract: To investigate the effects and mechanism of diosmetin on acute hepatic failure (AHF), an AHF murine model was established through administration of lipopolysaccharides/D-galactosamine (LPS/D-GalN). In vitro, diosmetin scavenged free radicals. In vivo, diosmetin decreased mortality… read more here.
Keywords: endotoxin induced; acute hepatic; hepatic failure; diosmetin ... See more keywords
Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2024.1464877
Abstract: The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,… read more here.
Keywords: diosmetin; pathway nicotiana; nicotiana benthamiana; pathway ... See more keywords
Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158687
Abstract: The skin acts as a mechanical barrier that protects the body from the exterior environment, and skin barrier function is attributed to the stratum corneum (SC), which is composed of keratinocytes and skin lipids. Skin… read more here.
Keywords: barrier function; spink5 lekti; skin barrier; diosmetin ... See more keywords
Investigation into the Antihypertensive Effects of Diosmetin and Its Underlying Vascular Mechanisms Using Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15080951
Abstract: Objective: Diosmetin is a flavonoid that is found in many important medicinal plants that have antihypertensive therapeutic potential. Diosmetin has been shown to have antiplatelet, anti-inflammatory and antioxidant properties, which suggests that it could be… read more here.
Keywords: investigation antihypertensive; diosmetin; name; antihypertensive effects ... See more keywords