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   Articles with "diosmin" as a keyword



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Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice

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recommendations! Published in 2019 at "Environmental Science and Pollution Research"

DOI: 10.1007/s11356-019-06572-2

Abstract: Paraquat (PQ) induces pulmonary fibrosis, a progressive lung disorder resulting in severe respiratory failure and death. Increased oxidative stress, inflammatory reactions, and multiple fibrotic lesions are major features of PQ-induced lung injury. Diosmin (Dio) is… read more here.

Keywords: induced lung; diosmin; lung injury; injury ... See more keywords
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Diosmin-loaded solid nanoparticles as nano-antioxidant therapy for management of hepatocellular carcinoma: QbD-based optimization, in vitro and in vivo evaluation

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recommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2020.102213

Abstract: Abstract The present work focuses on the development and evaluation of the diosmin-loaded solid lipid nanoparticles (SLNs) with the goal of improving its therapeutic efficacy in hepatic carcinoma (HCC) treatment. HCC was induced by administration… read more here.

Keywords: carcinoma; diosmin loaded; diosmin; evaluation ... See more keywords
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Post-ischemic reperfusion with diosmin attenuates myocardial injury through a nitric oxidase synthase-dependent mechanism.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118188

Abstract: Abstract Aims Diosmin is a citrus flavonoid with broad biological activities. Moreover, the administration of biologically active compounds during the myocardial reperfusion potentiates the cardioprotection and survival rate. Hence, this study aimed to evaluate whether… read more here.

Keywords: synthase; reperfusion diosmin; dependent mechanism; reperfusion ... See more keywords
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The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial.

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recommendations! Published in 2022 at "Journal of dietary supplements"

DOI: 10.1080/19390211.2022.2107138

Abstract: Current evidence supports the association of metabolic syndrome (MetS) with neuropathy. Limited data are available on proper strategies to control metabolic disorders and neuropathy among patients with type2 diabetes mellitus (T2DM). We aimed to determine… read more here.

Keywords: hesperidin diosmin; metabolic syndrome; combination; trial ... See more keywords
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Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

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recommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2017/3281670

Abstract: The current study was designed to investigate the beneficial role of diosmin, a biologically active flavonoid, against methotrexate- (MTX-) induced hepatic, renal, and cardiac injuries in mice. Male Swiss albino mice received a single intraperitoneal… read more here.

Keywords: hepatic renal; renal cardiac; diosmin; mtx induced ... See more keywords
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In vitro–in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin

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recommendations! Published in 2019 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s213836

Abstract: Background Diosmin showed poor water solubility and low bioavailability. Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were successfully used to improve the drugs solubility and bioavailability. Coating of PLGA nanoparticles with chitosan can ameliorate their gastric retention and cellular… read more here.

Keywords: gastric retention; microscopy; plga nanoparticles; diosmin ... See more keywords

Exploration of Diosmin to control diabitis and its complications-an in vitro and in silico approach.

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recommendations! Published in 2020 at "Current computer-aided drug design"

DOI: 10.2174/1573409916666200324135734

Abstract: BACKGROUND Diosmin is a flavonoid obtained from the citrus fruits of the plants. Diosmin has blood lipid lowering activities, antioxidant activity, enhances venous tone and microcirculation, protects capillaries, mainly by reducing systemic oxidative stress. OBJECTIVE… read more here.

Keywords: aldose reductase; amylase; diosmin; complications vitro ... See more keywords
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Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27238276

Abstract: Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid… read more here.

Keywords: diosmin tablets; tablets infrared; quantitative determination; spectroscopy ... See more keywords