Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-06572-2
Abstract: Paraquat (PQ) induces pulmonary fibrosis, a progressive lung disorder resulting in severe respiratory failure and death. Increased oxidative stress, inflammatory reactions, and multiple fibrotic lesions are major features of PQ-induced lung injury. Diosmin (Dio) is… read more here.
Keywords: induced lung; diosmin; lung injury; injury ... See more keywords
Diosmin-loaded solid nanoparticles as nano-antioxidant therapy for management of hepatocellular carcinoma: QbD-based optimization, in vitro and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.102213
Abstract: Abstract The present work focuses on the development and evaluation of the diosmin-loaded solid lipid nanoparticles (SLNs) with the goal of improving its therapeutic efficacy in hepatic carcinoma (HCC) treatment. HCC was induced by administration… read more here.
Keywords: carcinoma; diosmin loaded; diosmin; evaluation ... See more keywords
Post-ischemic reperfusion with diosmin attenuates myocardial injury through a nitric oxidase synthase-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118188
Abstract: Abstract Aims Diosmin is a citrus flavonoid with broad biological activities. Moreover, the administration of biologically active compounds during the myocardial reperfusion potentiates the cardioprotection and survival rate. Hence, this study aimed to evaluate whether… read more here.
Keywords: synthase; reperfusion diosmin; dependent mechanism; reperfusion ... See more keywords
Investigation of Ca2+ signaling induced by the flavonoid diosmin in glioblastoma cells and its potential implications in the treatment using the Ca2+ chelating agent BAPTA-AM
Sign Up to like & getrecommendations! Published in 2025 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2025.2501251
Abstract: Abstract Flavonoids, found in fruits and vegetables, can potentially prevent brain diseases. Diosmin (diosmetin-7-O-rutinoside), a flavonoid, exhibits various pharmacological activities, but its impact on calcium ion (Ca2+) signaling and the associated mechanisms in human glioblastoma… read more here.
Keywords: treatment; ca2 signaling; glioblastoma; ca2 ... See more keywords
The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dietary supplements"
DOI: 10.1080/19390211.2022.2107138
Abstract: Current evidence supports the association of metabolic syndrome (MetS) with neuropathy. Limited data are available on proper strategies to control metabolic disorders and neuropathy among patients with type2 diabetes mellitus (T2DM). We aimed to determine… read more here.
Keywords: hesperidin diosmin; metabolic syndrome; combination; trial ... See more keywords
Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/3281670
Abstract: The current study was designed to investigate the beneficial role of diosmin, a biologically active flavonoid, against methotrexate- (MTX-) induced hepatic, renal, and cardiac injuries in mice. Male Swiss albino mice received a single intraperitoneal… read more here.
Keywords: hepatic renal; renal cardiac; diosmin; mtx induced ... See more keywords
In vitro–in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s213836
Abstract: Background Diosmin showed poor water solubility and low bioavailability. Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were successfully used to improve the drugs solubility and bioavailability. Coating of PLGA nanoparticles with chitosan can ameliorate their gastric retention and cellular… read more here.
Keywords: gastric retention; microscopy; plga nanoparticles; diosmin ... See more keywords
Exploration of Diosmin to control diabitis and its complications-an in vitro and in silico approach.
Sign Up to like & getrecommendations! Published in 2020 at "Current computer-aided drug design"
DOI: 10.2174/1573409916666200324135734
Abstract: BACKGROUND Diosmin is a flavonoid obtained from the citrus fruits of the plants. Diosmin has blood lipid lowering activities, antioxidant activity, enhances venous tone and microcirculation, protects capillaries, mainly by reducing systemic oxidative stress. OBJECTIVE… read more here.
Keywords: aldose reductase; amylase; diosmin; complications vitro ... See more keywords
Comparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1655866
Abstract: Background Ovarian Hyper-stimulation Syndrome (OHSS) is the main iatrogenic problem linked to ovarian stimulation with reproductive medications. Increased vascular permeability is considered the cause of OHSS. It leads to excess fluid flowing from blood vessels… read more here.
Keywords: cabergoline; calcium gluconate; high risk; gluconate diosmin ... See more keywords
Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2024.1464877
Abstract: The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,… read more here.
Keywords: diosmetin; pathway nicotiana; nicotiana benthamiana; pathway ... See more keywords
Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238276
Abstract: Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid… read more here.
Keywords: diosmin tablets; tablets infrared; quantitative determination; spectroscopy ... See more keywords