Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer.
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DOI: 10.2139/ssrn.4232369
Abstract: Disruption of protein-protein interaction between transcriptional enhancer factor (TEA)-domain (TEAD; a transcription factor) and its co-activator Yes-associated protein (YAP)/ transcriptional co-activator with PDZ-binding motif (TAZ) is a potential therapeutic strategy against various types of solid… read more here.
Keywords: interaction inhibitors; breast cancer; benzo thiophene; dioxo benzo ... See more keywords